TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement

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TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement

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dc.contributor.author Bialas, Allison R. en_US
dc.contributor.author Stevens, Beth en_US
dc.date.accessioned 2014-07-07T17:03:55Z
dc.date.issued 2014 en_US
dc.identifier.citation Bialas, Allison R., and Beth Stevens. 2014. “TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement.” Nature neuroscience 16 (12): 1773-1782. doi:10.1038/nn.3560. http://dx.doi.org/10.1038/nn.3560. en
dc.identifier.issn 1097-6256 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406754
dc.description.abstract Immune molecules, including complement proteins C1q and C3, have emerged as critical mediators of synaptic refinement and plasticity. Complement localizes to synapses and refines the developing visual system via C3-dependent microglial phagocytosis of synapses. Retinal ganglion cells (RGCs) express C1q, the initiating protein of the classical complement cascade, during retinogeniculate refinement; however, the signals controlling C1q expression and function remain elusive. Previous work implicated an astrocyte-derived factor in regulating neuronal C1q expression. Here we identify retinal TGF-β as a key regulator of neuronal C1q expression and synaptic pruning in the developing visual system. Mice lacking TGF-β receptor II (TGFβRII) in retinal neurons have reduced C1q expression in RGCs, reduced synaptic localization of complement, and phenocopy refinement defects observed in complement-deficient mice, including reduced eye specific segregation and microglial engulfment of RGC inputs. These data implicate TGF-β in regulating neuronal C1q expression to initiate complement- and microglia-mediated synaptic pruning. en
dc.language.iso en_US en
dc.relation.isversionof doi:10.1038/nn.3560 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973738/pdf/ en
dash.license LAA en_US
dc.title TGF-β Signaling Regulates Neuronal C1q Expression and Developmental Synaptic Refinement en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Nature neuroscience en
dash.depositing.author Bialas, Allison R. en_US
dc.date.available 2014-07-07T17:03:55Z

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