STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

DSpace/Manakin Repository

STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b

Citable link to this page

 

 
Title: STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b
Author: Walker, Sarah R.; Xiang, Michael; Frank, David A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Walker, Sarah R., Michael Xiang, and David A. Frank. 2014. “STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b.” Cancers 6 (2): 958-968. doi:10.3390/cancers6020958. http://dx.doi.org/10.3390/cancers6020958.
Full Text & Related Files:
Abstract: The transcription factor STAT3 regulates genes that control critical cellular processes such as proliferation, survival, pluripotency, and motility. Thus, under physiological conditions, the transcriptional function of STAT3 is tightly regulated as one part of a complex signaling matrix. When these processes are subverted through mutation or epigenetic events, STAT3 becomes highly active and drives elevated expression of genes underlying these phenotypes, leading to malignant cellular behavior. However, even in the presence of activated STAT3, other cellular modulators can have a major impact on the biological properties of a cancer cell, which is reflected in the clinical behavior of a tumor. Recent evidence has suggested that two such key modulators are the activation status of other STAT family members, particularly STAT5, and the expression of STAT3-regulated genes that are part of negative feedback circuits, including microRNAs such as miR-146b. With attention to these newly emerging areas, we will gain greater insight into the consequence of STAT3 activation in the biology of human cancers. In addition, understanding these subtleties of STAT3 signaling in cancer pathogenesis will allow the development of more rational molecular approaches to cancer therapy.
Published Version: doi:10.3390/cancers6020958
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074811/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406758
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters