Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions

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Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions

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Title: Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions
Author: Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Kolind, Kristian; Dokmeci, Mehmet R.; Khademhosseini, Ali

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Citation: Dolatshahi-Pirouz, Alireza, Mehdi Nikkhah, Kristian Kolind, Mehmet R. Dokmeci, and Ali Khademhosseini. 2011. “Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions.” Journal of Functional Biomaterials 2 (3): 88-106. doi:10.3390/jfb2030088. http://dx.doi.org/10.3390/jfb2030088.
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Abstract: As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant progress in controlling stem cell differentiation, it is still difficult to engineer human tissue constructs for transplantation. Recent advances in micro- and nanofabrication techniques have enabled the design of more biomimetic biomaterials that may be used to direct the fate of stem cells. These biomaterials could have a significant impact on the next generation of stem cell based therapies. Here, we highlight the recent progress made by micro- and nanoengineering techniques in the biomaterials field in the context of directing stem cell differentiation. Particular attention is given to the effect of surface topography, chemistry, mechanics and micro- and nanopatterns on the differentiation of embryonic, mesenchymal and neural stem cells.
Published Version: doi:10.3390/jfb2030088
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030934/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406764
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