Aberrant regulation of FBW7 in cancer
Wang, ZhiweiNote: Order does not necessarily reflect citation order of authors.
MetadataShow full item record
CitationWang, Lixia, Xiantao Ye, Yueyong Liu, Wenyi Wei, and Zhiwei Wang. 2014. “Aberrant regulation of FBW7 in cancer.” Oncotarget 5 (8): 2000-2015.
AbstractFBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EBP2, Pin1, Hes-5 and Numb4 as well as by microRNAs such as miR-223, miR-27a, miR-25, and miR-129-5p. Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406786
- HMS Scholarly Articles