Aberrant regulation of FBW7 in cancer

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Aberrant regulation of FBW7 in cancer

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Title: Aberrant regulation of FBW7 in cancer
Author: Wang, Lixia; Ye, Xiantao; Liu, Yueyong; Wei, Wenyi; Wang, Zhiwei

Note: Order does not necessarily reflect citation order of authors.

Citation: Wang, Lixia, Xiantao Ye, Yueyong Liu, Wenyi Wei, and Zhiwei Wang. 2014. “Aberrant regulation of FBW7 in cancer.” Oncotarget 5 (8): 2000-2015.
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Abstract: FBW7 (F-box and WD repeat domain-containing 7) or Fbxw7 is a tumor suppressor, which promotes the ubiquitination and subsequent degradation of numerous oncoproteins including Mcl-1, Cyclin E, Notch, c- Jun, and c-Myc. In turn, FBW7 is regulated by multiple upstream factors including p53, C/EBP-δ, EBP2, Pin1, Hes-5 and Numb4 as well as by microRNAs such as miR-223, miR-27a, miR-25, and miR-129-5p. Given that the Fbw7 tumor suppressor is frequently inactivated or deleted in various human cancers, targeting FBW7 regulators is a promising anti-cancer therapeutic strategy.
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039140/pdf/
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Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406786
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