Independent and Combined Effects of Dietary Weight Loss and Exercise on Leukocyte Telomere Length in Postmenopausal Women
Duggan, Catherine R.
Campbell, Kristin L.
Foster-Schubert, Karen E.
Alfano, Catherine M.
Rabinovitch, Peter S.
McTiernan, AnneNote: Order does not necessarily reflect citation order of authors.
MetadataShow full item record
CitationMason, C., R. Risques, L. Xiao, C. R. Duggan, I. Imayama, K. L. Campbell, A. Kong, et al. 2013. “Independent and Combined Effects of Dietary Weight Loss and Exercise on Leukocyte Telomere Length in Postmenopausal Women.” Obesity (Silver Spring, Md.) 21 (12): 10.1002/oby.20509. doi:10.1002/oby.20509. http://dx.doi.org/10.1002/oby.20509.
AbstractObjective: Investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on leukocyte telomere length in postmenopausal women. Design and Methods 439 overweight or obese women (50–75 y) were randomized to: i) dietary weight loss (N=118); ii) aerobic exercise (N=117), iii) diet + exercise (N=117), or iv) control (N=87). The diet intervention was a group-based program with a 10% weight loss goal. The exercise intervention was 45 mins/day, 5 days/week of moderate-to-vigorous aerobic activity. Fasting blood samples were taken at baseline and 12 months. DNA was extracted from isolated leukocytes and telomere length was measured by quantitative-polymerase chain reaction (qPCR). Mean changes were compared between groups (intent-to-treat) using generalized estimating equations. Results: Baseline telomere length was inversely associated with age (r=−0.12 p<0.01) and positively associated with maximal oxygen uptake (r=0.11, p=0.03), but not with BMI or %body fat. Change in telomere length was inversely correlated with baseline telomere length (r=−0.47, p<0.0001). No significant difference in leukocyte telomere length was detected in any intervention group compared to controls, nor was the magnitude of weight loss associated with telomere length at 12 months. Conclusions: Twelve-months of dietary weight loss and exercise did not change telomere length in postmenopausal women.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406793
- HMS Scholarly Articles