Independent and Combined Effects of Dietary Weight Loss and Exercise on Leukocyte Telomere Length in Postmenopausal Women
View/ Open
Author
Mason, Caitlin
Risques, Rosa-Ana
Xiao, Liren
Duggan, Catherine R.
Imayama, Ikuyo
Campbell, Kristin L.
Kong, Angela
Foster-Schubert, Karen E.
Wang, CY
Alfano, Catherine M.
Rabinovitch, Peter S.
McTiernan, Anne
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1002/oby.20509Metadata
Show full item recordCitation
Mason, C., R. Risques, L. Xiao, C. R. Duggan, I. Imayama, K. L. Campbell, A. Kong, et al. 2013. “Independent and Combined Effects of Dietary Weight Loss and Exercise on Leukocyte Telomere Length in Postmenopausal Women.” Obesity (Silver Spring, Md.) 21 (12): 10.1002/oby.20509. doi:10.1002/oby.20509. http://dx.doi.org/10.1002/oby.20509.Abstract
Objective: Investigate the effects of 12 months of dietary weight loss and/or aerobic exercise on leukocyte telomere length in postmenopausal women. Design and Methods 439 overweight or obese women (50–75 y) were randomized to: i) dietary weight loss (N=118); ii) aerobic exercise (N=117), iii) diet + exercise (N=117), or iv) control (N=87). The diet intervention was a group-based program with a 10% weight loss goal. The exercise intervention was 45 mins/day, 5 days/week of moderate-to-vigorous aerobic activity. Fasting blood samples were taken at baseline and 12 months. DNA was extracted from isolated leukocytes and telomere length was measured by quantitative-polymerase chain reaction (qPCR). Mean changes were compared between groups (intent-to-treat) using generalized estimating equations. Results: Baseline telomere length was inversely associated with age (r=−0.12 p<0.01) and positively associated with maximal oxygen uptake (r=0.11, p=0.03), but not with BMI or %body fat. Change in telomere length was inversely correlated with baseline telomere length (r=−0.47, p<0.0001). No significant difference in leukocyte telomere length was detected in any intervention group compared to controls, nor was the magnitude of weight loss associated with telomere length at 12 months. Conclusions: Twelve-months of dietary weight loss and exercise did not change telomere length in postmenopausal women.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786031/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406793
Collections
- HMS Scholarly Articles [17917]
Contact administrator regarding this item (to report mistakes or request changes)