SIRT6 Is Required for Normal Retinal Function

DSpace/Manakin Repository

SIRT6 Is Required for Normal Retinal Function

Citable link to this page

 

 
Title: SIRT6 Is Required for Normal Retinal Function
Author: Silberman, Dafne M.; Ross, Kenneth; Sande, Pablo H.; Kubota, Shunsuke; Ramaswamy, Sridhar; Apte, Rajendra S.; Mostoslavsky, Raul

Note: Order does not necessarily reflect citation order of authors.

Citation: Silberman, Dafne M., Kenneth Ross, Pablo H. Sande, Shunsuke Kubota, Sridhar Ramaswamy, Rajendra S. Apte, and Raul Mostoslavsky. 2014. “SIRT6 Is Required for Normal Retinal Function.” PLoS ONE 9 (6): e98831. doi:10.1371/journal.pone.0098831. http://dx.doi.org/10.1371/journal.pone.0098831.
Full Text & Related Files:
Abstract: The retina is one of the major energy consuming tissues within the body. In this context, synaptic transmission between light-excited rod and cone photoreceptors and downstream ON-bipolar neurons is a highly demanding energy consuming process. Sirtuin 6 (SIRT6), a NAD-dependent deacylase, plays a key role in regulating glucose metabolism. In this study, we demonstrate that SIRT6 is highly expressed in the retina, controlling levels of histone H3K9 and H3K56 acetylation. Notably, despite apparent normal histology, SIRT6 deficiency caused major retinal transmission defects concomitant to changes in expression of glycolytic genes and glutamate receptors, as well as elevated levels of apoptosis in inner retina cells. Our results identify SIRT6 as a critical modulator of retinal function, likely through its effects on chromatin.
Published Version: doi:10.1371/journal.pone.0098831
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045872/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406814
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters