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dc.contributor.authorSong, Men_US
dc.contributor.authorWu, Ken_US
dc.contributor.authorOgino, Sen_US
dc.contributor.authorFuchs, C Sen_US
dc.contributor.authorGiovannucci, E Len_US
dc.contributor.authorChan, A Ten_US
dc.date.accessioned2014-07-07T18:12:56Z
dc.date.issued2013en_US
dc.identifier.citationSong, M, K Wu, S Ogino, C S Fuchs, E L Giovannucci, and A T Chan. 2013. “A prospective study of plasma inflammatory markers and risk of colorectal cancer in men.” British Journal of Cancer 108 (9): 1891-1898. doi:10.1038/bjc.2013.172. http://dx.doi.org/10.1038/bjc.2013.172.en
dc.identifier.issn0007-0920en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406833
dc.description.abstractBackground: Chronic inflammation may mediate risk of colorectal cancer (CRC); however, the association between circulating inflammatory markers and risk of CRC has been inconsistent. Methods: We prospectively evaluated the association of plasma C-reactive protein (CRP), interleukin-6 (IL-6), and the soluble tumour necrosis factor receptor 2 (sTNFR-2) with incident CRC among 274 cases and 532 matched controls nested in the Health Professionals Follow-up Study. Results: Multivariate relative risk (RR) of CRC comparing the extreme quartiles of plasma IL-6 was 1.54 (95% confidence interval (CI), 0.99–2.40; Ptrend=0.02). However, after excluding cases diagnosed within 2 years of blood draw, this association was not statistically significant (RR=1.26, 95% CI, 0.78–2.05; Ptrend=0.21). In analyses restricted to cases diagnosed at least 2 years after blood draw, the association of IL-6 with CRC appeared to differ by body mass index such that the significantly positive association was only present among lean individuals (Pinteraction=0.03). We did not observe any significant association between CRP or sTNFR-2 and CRC. Conclusion: Plasma inflammatory markers are not generally associated with risk of CRC among men. However, the possibility that plasma IL-6 is associated with increased risk of CRC among lean men requires further investigation.en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.relation.isversionofdoi:10.1038/bjc.2013.172en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658520/pdf/en
dash.licenseLAAen_US
dc.subjectC-reactive proteinen
dc.subjectinterleukin-6en
dc.subjectsoluble tumour necrosis factor receptor 2en
dc.subjectcolorectal canceren
dc.subjectbody mass indexen
dc.titleA prospective study of plasma inflammatory markers and risk of colorectal cancer in menen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBritish Journal of Canceren
dc.date.available2014-07-07T18:12:56Z
dc.identifier.doi10.1038/bjc.2013.172*


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