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dc.contributor.authorChen, Maxine M.en_US
dc.contributor.authorCrous-Bou, Martaen_US
dc.contributor.authorSetiawan, Veronica W.en_US
dc.contributor.authorPrescott, Jenniferen_US
dc.contributor.authorOlson, Sara H.en_US
dc.contributor.authorWentzensen, Nicolasen_US
dc.contributor.authorBlack, Amandaen_US
dc.contributor.authorBrinton, Louiseen_US
dc.contributor.authorChen, Chuen_US
dc.contributor.authorChen, Constanceen_US
dc.contributor.authorCook, Linda S.en_US
dc.contributor.authorDoherty, Jenniferen_US
dc.contributor.authorFriedenreich, Christine M.en_US
dc.contributor.authorHankinson, Susan E.en_US
dc.contributor.authorHartge, Patriciaen_US
dc.contributor.authorHenderson, Brian E.en_US
dc.contributor.authorHunter, David J.en_US
dc.contributor.authorLe Marchand, Loicen_US
dc.contributor.authorLiang, Xiaolinen_US
dc.contributor.authorLissowska, Jolantaen_US
dc.contributor.authorLu, Lingengen_US
dc.contributor.authorOrlow, Ireneen_US
dc.contributor.authorPetruzella, Staceyen_US
dc.contributor.authorPolidoro, Silviaen_US
dc.contributor.authorPooler, Loreallen_US
dc.contributor.authorRebbeck, Timothy R.en_US
dc.contributor.authorRisch, Harveyen_US
dc.contributor.authorSacerdote, Carlottaen_US
dc.contributor.authorSchumacher, Fredericken_US
dc.contributor.authorSheng, Xinen_US
dc.contributor.authorShu, Xiao-ouen_US
dc.contributor.authorWeiss, Noel S.en_US
dc.contributor.authorXia, Lucyen_US
dc.contributor.authorVan Den Berg, Daviden_US
dc.contributor.authorYang, Hannah P.en_US
dc.contributor.authorYu, Herberten_US
dc.contributor.authorChanock, Stephenen_US
dc.contributor.authorHaiman, Christopheren_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorDe Vivo, Immaculataen_US
dc.date.accessioned2014-07-07T18:12:56Z
dc.date.issued2014en_US
dc.identifier.citationChen, M. M., M. Crous-Bou, V. W. Setiawan, J. Prescott, S. H. Olson, N. Wentzensen, A. Black, et al. 2014. “Exome-Wide Association Study of Endometrial Cancer in a Multiethnic Population.” PLoS ONE 9 (5): e97045. doi:10.1371/journal.pone.0097045. http://dx.doi.org/10.1371/journal.pone.0097045.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406834
dc.description.abstractEndometrial cancer (EC) contributes substantially to total burden of cancer morbidity and mortality in the United States. Family history is a known risk factor for EC, thus genetic factors may play a role in EC pathogenesis. Three previous genome-wide association studies (GWAS) have found only one locus associated with EC, suggesting that common variants with large effects may not contribute greatly to EC risk. Alternatively, we hypothesize that rare variants may contribute to EC risk. We conducted an exome-wide association study (EXWAS) of EC using the Infinium HumanExome BeadChip in order to identify rare variants associated with EC risk. We successfully genotyped 177,139 variants in a multiethnic population of 1,055 cases and 1,778 controls from four studies that were part of the Epidemiology of Endometrial Cancer Consortium (E2C2). No variants reached global significance in the study, suggesting that more power is needed to detect modest associations between rare genetic variants and risk of EC.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0097045en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014590/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectGeneticsen
dc.subjectCancer Geneticsen
dc.subjectHuman Geneticsen
dc.subjectMedicine and Health Sciencesen
dc.subjectEpidemiologyen
dc.subjectCancer Epidemiologyen
dc.subjectOncologyen
dc.subjectCancer Risk Factorsen
dc.subjectGenetic Causes of Canceren
dc.subjectCancers and Neoplasmsen
dc.subjectGynecological Tumorsen
dc.subjectWomen's Healthen
dc.subjectObstetrics and Gynecologyen
dc.subjectGynecologic Cancersen
dc.titleExome-Wide Association Study of Endometrial Cancer in a Multiethnic Populationen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorChen, Maxine M.en_US
dc.date.available2014-07-07T18:12:56Z
dc.identifier.doi10.1371/journal.pone.0097045*
dash.authorsorderedfalse
dash.contributor.affiliatedPrescott, Jennifer
dash.contributor.affiliatedHankinson, Susan
dash.contributor.affiliatedChen, Maxine M.
dash.contributor.affiliatedDe Vivo, Immaculata
dash.contributor.affiliatedHunter, David
dash.contributor.affiliatedKraft, Phillip
dc.identifier.orcid0000-0001-7138-6228


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