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dc.contributor.authorBraun, Joseph M.en_US
dc.contributor.authorKalkbrenner, Amy E.en_US
dc.contributor.authorJust, Allan C.en_US
dc.contributor.authorYolton, Kimberlyen_US
dc.contributor.authorCalafat, Antonia M.en_US
dc.contributor.authorSjödin, Andreasen_US
dc.contributor.authorHauser, Russen_US
dc.contributor.authorWebster, Glenys M.en_US
dc.contributor.authorChen, Aiminen_US
dc.contributor.authorLanphear, Bruce P.en_US
dc.date.accessioned2014-07-07T18:12:57Z
dc.date.issued2014en_US
dc.identifier.citationBraun, Joseph M., Amy E. Kalkbrenner, Allan C. Just, Kimberly Yolton, Antonia M. Calafat, Andreas Sjödin, Russ Hauser, Glenys M. Webster, Aimin Chen, and Bruce P. Lanphear. 2014. “Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study.” Environmental Health Perspectives 122 (5): 513-520. doi:10.1289/ehp.1307261. http://dx.doi.org/10.1289/ehp.1307261.en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406835
dc.description.abstractBackground: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors. Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs. Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (≤ 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (β = 2.5; 95% CI: –0.6, 5.6) or trans-nonachlor (β = 4.1; 95% CI: 0.8–7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (β = –3.0; 95% CI: –6.3, 0.2), β-hexachlorocyclohexane (β = –3.3; 95% CI: –6.1, –0.5), or PBDE-85 (β = –3.2; 95% CI: –5.9, –0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (β = –2.0; 95% CI: –4.4, 0.4). Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, β-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors. Citation: Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A, Lanphear BP. 2014. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME Study. Environ Health Perspect 122:513–520; http://dx.doi.org/10.1289/ehp.1307261en
dc.language.isoen_USen
dc.publisherNLM-Exporten
dc.relation.isversionofdoi:10.1289/ehp.1307261en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014765/pdf/en
dash.licenseLAAen_US
dc.titleGestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEnvironmental Health Perspectivesen
dash.depositing.authorHauser, Russen_US
dc.date.available2014-07-07T18:12:57Z
dc.identifier.doi10.1289/ehp.1307261*
dash.contributor.affiliatedHauser, Russ


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