Selectivity in Genetic Association with Sub-classified Migraine in Women

DSpace/Manakin Repository

Selectivity in Genetic Association with Sub-classified Migraine in Women

Citable link to this page

 

 
Title: Selectivity in Genetic Association with Sub-classified Migraine in Women
Author: Chasman, Daniel I.; Anttila, Verneri; Buring, Julie E.; Ridker, Paul M.; Schürks, Markus; Kurth, Tobias

Note: Order does not necessarily reflect citation order of authors.

Citation: Chasman, Daniel I., Verneri Anttila, Julie E. Buring, Paul M. Ridker, Markus Schürks, and Tobias Kurth. 2014. “Selectivity in Genetic Association with Sub-classified Migraine in Women.” PLoS Genetics 10 (5): e1004366. doi:10.1371/journal.pgen.1004366. http://dx.doi.org/10.1371/journal.pgen.1004366.
Full Text & Related Files:
Abstract: Migraine can be sub-classified not only according to presence of migraine aura (MA) or absence of migraine aura (MO), but also by additional features accompanying migraine attacks, e.g. photophobia, phonophobia, nausea, etc. all of which are formally recognized by the International Classification of Headache Disorders. It remains unclear how aura status and the other migraine features may be related to underlying migraine pathophysiology. Recent genome-wide association studies (GWAS) have identified 12 independent loci at which single nucleotide polymorphisms (SNPs) are associated with migraine. Using a likelihood framework, we explored the selective association of these SNPs with migraine, sub-classified according to aura status and the other features in a large population-based cohort of women including 3,003 active migraineurs and 18,108 free of migraine. Five loci met stringent significance for association with migraine, among which four were selective for sub-classified migraine, including rs11172113 (LRP1) for MO. The number of loci associated with migraine increased to 11 at suggestive significance thresholds, including five additional selective associations for MO but none for MA. No two SNPs showed similar patterns of selective association with migraine characteristics. At one extreme, SNPs rs6790925 (near TGFBR2) and rs2274316 (MEF2D) were not associated with migraine overall, MA, or MO but were selective for migraine sub-classified by the presence of one or more of the additional migraine features. In contrast, SNP rs7577262 (TRPM8) was associated with migraine overall and showed little or no selectivity for any of the migraine characteristics. The results emphasize the multivalent nature of migraine pathophysiology and suggest that a complete understanding of the genetic influence on migraine may benefit from analyses that stratify migraine according to both aura status and the additional diagnostic features used for clinical characterization of migraine.
Published Version: doi:10.1371/journal.pgen.1004366
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031047/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406858
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters