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dc.contributor.authorGraff, Mariaelisaen_US
dc.contributor.authorGordon-Larsen, Pennyen_US
dc.contributor.authorLim, Unheeen_US
dc.contributor.authorFowke, Jay H.en_US
dc.contributor.authorLove, Shelly-Annen_US
dc.contributor.authorFesinmeyer, Meganen_US
dc.contributor.authorWilkens, Lynne R.en_US
dc.contributor.authorVertilus, Shawynteeen_US
dc.contributor.authorRitchie, Marilyn D.en_US
dc.contributor.authorPrentice, Ross L.en_US
dc.contributor.authorPankow, Jimen_US
dc.contributor.authorMonroe, Kristineen_US
dc.contributor.authorManson, JoAnn E.en_US
dc.contributor.authorLe Marchand, Loïcen_US
dc.contributor.authorKuller, Lewis H.en_US
dc.contributor.authorKolonel, Laurence N.en_US
dc.contributor.authorHong, Ching P.en_US
dc.contributor.authorHenderson, Brian E.en_US
dc.contributor.authorHaessler, Jeffen_US
dc.contributor.authorGross, Myron D.en_US
dc.contributor.authorGoodloe, Roberten_US
dc.contributor.authorFranceschini, Noraen_US
dc.contributor.authorCarlson, Christopher S.en_US
dc.contributor.authorBuyske, Stevenen_US
dc.contributor.authorBůžková, Petraen_US
dc.contributor.authorHindorff, Lucia A.en_US
dc.contributor.authorMatise, Tara C.en_US
dc.contributor.authorCrawford, Dana C.en_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorPeters, Ulrikeen_US
dc.contributor.authorNorth, Kari E.en_US
dc.date.accessioned2014-07-07T18:13:11Z
dc.date.issued2013en_US
dc.identifier.citationGraff, M., P. Gordon-Larsen, U. Lim, J. H. Fowke, S. Love, M. Fesinmeyer, L. R. Wilkens, et al. 2013. “The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study.” Diabetes 62 (5): 1763-1767. doi:10.2337/db12-0863. http://dx.doi.org/10.2337/db12-0863.en
dc.identifier.issn0012-1797en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406864
dc.description.abstractEvidence is limited as to whether heritable risk of obesity varies throughout adulthood. Among >34,000 European Americans, aged 18–100 years, from multiple U.S. studies in the Population Architecture using Genomics and Epidemiology (PAGE) Consortium, we examined evidence for heterogeneity in the associations of five established obesity risk variants (near FTO, GNPDA2, MTCH2, TMEM18, and NEGR1) with BMI across four distinct epochs of adulthood: 1) young adulthood (ages 18–25 years), adulthood (ages 26–49 years), middle-age adulthood (ages 50–69 years), and older adulthood (ages ≥70 years); or 2) by menopausal status in women and stratification by age 50 years in men. Summary-effect estimates from each meta-analysis were compared for heterogeneity across the life epochs. We found heterogeneity in the association of the FTO (rs8050136) variant with BMI across the four adulthood epochs (P = 0.0006), with larger effects in young adults relative to older adults (β [SE] = 1.17 [0.45] vs. 0.09 [0.09] kg/m2, respectively, per A allele) and smaller intermediate effects. We found no evidence for heterogeneity in the association of GNPDA2, MTCH2, TMEM18, and NEGR1 with BMI across adulthood. Genetic predisposition to obesity may have greater effects on body weight in young compared with older adulthood for FTO, suggesting changes by age, generation, or secular trends. Future research should compare and contrast our findings with results using longitudinal data.en
dc.language.isoen_USen
dc.publisherAmerican Diabetes Associationen
dc.relation.isversionofdoi:10.2337/db12-0863en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636619/pdf/en
dash.licenseLAAen_US
dc.subjectGenetics/Genomes/Proteomics/Metabolomicsen
dc.titleThe Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetesen
dash.depositing.authorManson, JoAnn E.en_US
dc.date.available2014-07-07T18:13:11Z
dc.identifier.doi10.2337/db12-0863*
dash.authorsorderedfalse
dash.contributor.affiliatedManson, JoAnn
dc.identifier.orcid0000-0002-9426-7595


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