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dc.contributor.authorKoivula, Robert W.en_US
dc.contributor.authorHeggie, Alisonen_US
dc.contributor.authorBarnett, Annaen_US
dc.contributor.authorCederberg, Hennaen_US
dc.contributor.authorHansen, Tue H.en_US
dc.contributor.authorKoopman, Anitra D.en_US
dc.contributor.authorRidderstråle, Martinen_US
dc.contributor.authorRutters, Femkeen_US
dc.contributor.authorVestergaard, Henriken_US
dc.contributor.authorGupta, Ramneeken_US
dc.contributor.authorHerrgård, Sannaen_US
dc.contributor.authorHeymans, Martijn W.en_US
dc.contributor.authorPerry, Mandy H.en_US
dc.contributor.authorRauh, Simoneen_US
dc.contributor.authorSiloaho, Marittaen_US
dc.contributor.authorTeare, Harriet J. A.en_US
dc.contributor.authorThorand, Barbaraen_US
dc.contributor.authorBell, Jimmyen_US
dc.contributor.authorBrunak, Sørenen_US
dc.contributor.authorFrost, Garyen_US
dc.contributor.authorJablonka, Bernden_US
dc.contributor.authorMari, Andreaen_US
dc.contributor.authorMcDonald, Tim J.en_US
dc.contributor.authorDekker, Jacqueline M.en_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorHattersley, Andrewen_US
dc.contributor.authorLaakso, Markkuen_US
dc.contributor.authorPedersen, Olufen_US
dc.contributor.authorKoivisto, Veikkoen_US
dc.contributor.authorRuetten, Hartmuten_US
dc.contributor.authorWalker, Marken_US
dc.contributor.authorPearson, Ewanen_US
dc.contributor.authorFranks, Paul W.en_US
dc.date.accessioned2014-07-07T18:13:22Z
dc.date.issued2014en_US
dc.identifier.citationKoivula, R. W., A. Heggie, A. Barnett, H. Cederberg, T. H. Hansen, A. D. Koopman, M. Ridderstråle, et al. 2014. “Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.” Diabetologia 57 (1): 1132-1142. doi:10.1007/s00125-014-3216-x. http://dx.doi.org/10.1007/s00125-014-3216-x.en
dc.identifier.issn0012-186Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406876
dc.description.abstractAims/hypothesis The DIRECT (Diabetes Research on Patient Stratification) Study is part of a European Union Framework 7 Innovative Medicines Initiative project, a joint undertaking between four industry and 21 academic partners throughout Europe. The Consortium aims to discover and validate biomarkers that: (1) predict the rate of glycaemic deterioration before and after type 2 diabetes onset; (2) predict the response to diabetes therapies; and (3) help stratify type 2 diabetes into clearly definable disease subclasses that can be treated more effectively than without stratification. This paper describes two new prospective cohort studies conducted as part of DIRECT. Methods: Prediabetic participants (target sample size 2,200–2,700) and patients with newly diagnosed type 2 diabetes (target sample size ~1,000) are undergoing detailed metabolic phenotyping at baseline and 18 months and 36 months later. Abdominal, pancreatic and liver fat is assessed using MRI. Insulin secretion and action are assessed using frequently sampled OGTTs in non-diabetic participants, and frequently sampled mixed-meal tolerance tests in patients with type 2 diabetes. Biosamples include venous blood, faeces, urine and nail clippings, which, among other biochemical analyses, will be characterised at genetic, transcriptomic, metabolomic, proteomic and metagenomic levels. Lifestyle is assessed using high-resolution triaxial accelerometry, 24 h diet record, and food habit questionnaires. Conclusions/interpretation DIRECT will yield an unprecedented array of biomaterials and data. This resource, available through managed access to scientists within and outside the Consortium, will facilitate the development of new treatments and therapeutic strategies for the prevention and management of type 2 diabetes. Electronic supplementary material The online version of this article (doi:10.1007/s00125-014-3216-x) contains peer-reviewed but unedited supplementary material, which is available to authorised users.en
dc.language.isoen_USen
dc.publisherSpringer Berlin Heidelbergen
dc.relation.isversionofdoi:10.1007/s00125-014-3216-xen
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018481/pdf/en
dash.licenseLAAen_US
dc.subjectEpigeneticen
dc.subjectGene–environment interactionen
dc.subjectGenomeen
dc.subjectGlycaemic controlen
dc.subjectLifestyleen
dc.subjectMicrobiomeen
dc.subjectPrediabetesen
dc.subjectProteomeen
dc.subjectTranscriptomeen
dc.subjectType 2 diabetesen
dc.titleDiscovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortiumen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetologiaen
dc.date.available2014-07-07T18:13:22Z
dc.identifier.doi10.1007/s00125-014-3216-x*
dash.authorsorderedfalse


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