Systems analysis of the CO2 concentrating mechanism in cyanobacteria

DSpace/Manakin Repository

Systems analysis of the CO2 concentrating mechanism in cyanobacteria

Citable link to this page

 

 
Title: Systems analysis of the CO2 concentrating mechanism in cyanobacteria
Author: Mangan, Niall M; Brenner, Michael P

Note: Order does not necessarily reflect citation order of authors.

Citation: Mangan, Niall M., and Michael P Brenner. 2014. “Systems analysis of the CO2 concentrating mechanism in cyanobacteria.” eLife 3 (1): e02043. doi:10.7554/eLife.02043. http://dx.doi.org/10.7554/eLife.02043.
Full Text & Related Files:
Abstract: Cyanobacteria are photosynthetic bacteria with a unique CO2 concentrating mechanism (CCM), enhancing carbon fixation. Understanding the CCM requires a systems level perspective of how molecular components work together to enhance CO2 fixation. We present a mathematical model of the cyanobacterial CCM, giving the parameter regime (expression levels, catalytic rates, permeability of carboxysome shell) for efficient carbon fixation. Efficiency requires saturating the RuBisCO reaction, staying below saturation for carbonic anhydrase, and avoiding wasteful oxygenation reactions. We find selectivity at the carboxysome shell is not necessary; there is an optimal non-specific carboxysome shell permeability. We compare the efficacy of facilitated CO2 uptake, CO2 scavenging, and HCO3− transport with varying external pH. At the optimal carboxysome permeability, contributions from CO2 scavenging at the cell membrane are small. We examine the cumulative benefits of CCM spatial organization strategies: enzyme co-localization and compartmentalization. DOI: http://dx.doi.org/10.7554/eLife.02043.001
Published Version: doi:10.7554/eLife.02043
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027813/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406910
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters