Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Show simple item record Beecham, Ashley H en_US Patsopoulos, Nikolaos A en_US Xifara, Dionysia K en_US Davis, Mary F en_US Kemppinen, Anu en_US Cotsapas, Chris en_US Shahi, Tejas S en_US Spencer, Chris en_US Booth, David en_US Goris, An en_US Oturai, Annette en_US Saarela, Janna en_US Fontaine, Bertrand en_US Hemmer, Bernhard en_US Martin, Claes en_US Zipp, Frauke en_US D’alfonso, Sandra en_US Martinelli-Boneschi, Filippo en_US Taylor, Bruce en_US Harbo, Hanne F en_US Kockum, Ingrid en_US Hillert, Jan en_US Olsson, Tomas en_US Ban, Maria en_US Oksenberg, Jorge R en_US Hintzen, Rogier en_US Barcellos, Lisa F en_US Agliardi, Cristina en_US Alfredsson, Lars en_US Alizadeh, Mehdi en_US Anderson, Carl en_US Andrews, Robert en_US Søndergaard, Helle Bach en_US Baker, Amie en_US Band, Gavin en_US Baranzini, Sergio E en_US Barizzone, Nadia en_US Barrett, Jeffrey en_US Bellenguez, Céline en_US Bergamaschi, Laura en_US Bernardinelli, Luisa en_US Berthele, Achim en_US Biberacher, Viola en_US Binder, Thomas M C en_US Blackburn, Hannah en_US Bomfim, Izaura L en_US Brambilla, Paola en_US Broadley, Simon en_US Brochet, Bruno en_US Brundin, Lou en_US Buck, Dorothea en_US Butzkueven, Helmut en_US Caillier, Stacy J en_US Camu, William en_US Carpentier, Wassila en_US Cavalla, Paola en_US Celius, Elisabeth G en_US Coman, Irène en_US Comi, Giancarlo en_US Corrado, Lucia en_US Cosemans, Leentje en_US Cournu-Rebeix, Isabelle en_US Cree, Bruce A C en_US Cusi, Daniele en_US Damotte, Vincent en_US Defer, Gilles en_US Delgado, Silvia R en_US Deloukas, Panos en_US di Sapio, Alessia en_US Dilthey, Alexander T en_US Donnelly, Peter en_US Dubois, Bénédicte en_US Duddy, Martin en_US Edkins, Sarah en_US Elovaara, Irina en_US Esposito, Federica en_US Evangelou, Nikos en_US Fiddes, Barnaby en_US Field, Judith en_US Franke, Andre en_US Freeman, Colin en_US Frohlich, Irene Y en_US Galimberti, Daniela en_US Gieger, Christian en_US Gourraud, Pierre-Antoine en_US Graetz, Christiane en_US Graham, Andrew en_US Grummel, Verena en_US Guaschino, Clara en_US Hadjixenofontos, Athena en_US Hakonarson, Hakon en_US Halfpenny, Christopher en_US Hall, Gillian en_US Hall, Per en_US Hamsten, Anders en_US Harley, James en_US Harrower, Timothy en_US Hawkins, Clive en_US Hellenthal, Garrett en_US Hillier, Charles en_US Hobart, Jeremy en_US Hoshi, Muni en_US Hunt, Sarah E en_US Jagodic, Maja en_US Jelčić, Ilijas en_US Jochim, Angela en_US Kendall, Brian en_US Kermode, Allan en_US Kilpatrick, Trevor en_US Koivisto, Keijo en_US Konidari, Ioanna en_US Korn, Thomas en_US Kronsbein, Helena en_US Langford, Cordelia en_US Larsson, Malin en_US Lathrop, Mark en_US Lebrun-Frenay, Christine en_US Lechner-Scott, Jeannette en_US Lee, Michelle H en_US Leone, Maurizio A en_US Leppä, Virpi en_US Liberatore, Giuseppe en_US Lie, Benedicte A en_US Lill, Christina M en_US Lindén, Magdalena en_US Link, Jenny en_US Luessi, Felix en_US Lycke, Jan en_US Macciardi, Fabio en_US Männistö, Satu en_US Manrique, Clara P en_US Martin, Roland en_US Martinelli, Vittorio en_US Mason, Deborah en_US Mazibrada, Gordon en_US McCabe, Cristin en_US Mero, Inger-Lise en_US Mescheriakova, Julia en_US Moutsianas, Loukas en_US Myhr, Kjell-Morten en_US Nagels, Guy en_US Nicholas, Richard en_US Nilsson, Petra en_US Piehl, Fredrik en_US Pirinen, Matti en_US Price, Siân E en_US Quach, Hong en_US Reunanen, Mauri en_US Robberecht, Wim en_US Robertson, Neil P en_US Rodegher, Mariaemma en_US Rog, David en_US Salvetti, Marco en_US Schnetz-Boutaud, Nathalie C en_US Sellebjerg, Finn en_US Selter, Rebecca C en_US Schaefer, Catherine en_US Shaunak, Sandip en_US Shen, Ling en_US Shields, Simon en_US Siffrin, Volker en_US Slee, Mark en_US Sorensen, Per Soelberg en_US Sorosina, Melissa en_US Sospedra, Mireia en_US Spurkland, Anne en_US Strange, Amy en_US Sundqvist, Emilie en_US Thijs, Vincent en_US Thorpe, John en_US Ticca, Anna en_US Tienari, Pentti en_US van Duijn, Cornelia en_US Visser, Elizabeth M en_US Vucic, Steve en_US Westerlind, Helga en_US Wiley, James S en_US Wilkins, Alastair en_US Wilson, James F en_US Winkelmann, Juliane en_US Zajicek, John en_US Zindler, Eva en_US Haines, Jonathan L en_US Pericak-Vance, Margaret A en_US Ivinson, Adrian J en_US Stewart, Graeme en_US Hafler, David en_US Hauser, Stephen L en_US Compston, Alastair en_US McVean, Gil en_US De Jager, Philip en_US Sawcer, Stephen en_US McCauley, Jacob L en_US 2014-07-07T18:14:37Z 2013 en_US
dc.identifier.citation Beecham, A. H., N. A. Patsopoulos, D. K. Xifara, M. F. Davis, A. Kemppinen, C. Cotsapas, T. S. Shahi, et al. 2013. “Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.” Nature genetics 45 (11): 10.1038/ng.2770. doi:10.1038/ng.2770. en
dc.identifier.issn 1061-4036 en
dc.description.abstract Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 × 10-4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 multiple sclerosis subjects and 26,703 healthy controls. In these 80,094 individuals of European ancestry we identified 48 new susceptibility variants (p-value < 5.0 × 10-8); three found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants in 103 discrete loci outside of the Major Histocompatibility Complex. With high resolution Bayesian fine-mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalogue of multiple sclerosis risk variants and illustrates the value of fine-mapping in the resolution of GWAS signals. en
dc.language.iso en_US en
dc.relation.isversionof doi:10.1038/ng.2770 en
dc.relation.hasversion en
dash.license LAA en_US
dc.title Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Nature genetics en Patsopoulos, Nikolaos A en_US 2014-07-07T18:14:37Z

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