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dc.contributor.authorBeecham, Ashley Hen_US
dc.contributor.authorPatsopoulos, Nikolaos Aen_US
dc.contributor.authorXifara, Dionysia Ken_US
dc.contributor.authorDavis, Mary Fen_US
dc.contributor.authorKemppinen, Anuen_US
dc.contributor.authorCotsapas, Chrisen_US
dc.contributor.authorShahi, Tejas Sen_US
dc.contributor.authorSpencer, Chrisen_US
dc.contributor.authorBooth, Daviden_US
dc.contributor.authorGoris, Anen_US
dc.contributor.authorOturai, Annetteen_US
dc.contributor.authorSaarela, Jannaen_US
dc.contributor.authorFontaine, Bertranden_US
dc.contributor.authorHemmer, Bernharden_US
dc.contributor.authorMartin, Claesen_US
dc.contributor.authorZipp, Fraukeen_US
dc.contributor.authorD’alfonso, Sandraen_US
dc.contributor.authorMartinelli-Boneschi, Filippoen_US
dc.contributor.authorTaylor, Bruceen_US
dc.contributor.authorHarbo, Hanne Fen_US
dc.contributor.authorKockum, Ingriden_US
dc.contributor.authorHillert, Janen_US
dc.contributor.authorOlsson, Tomasen_US
dc.contributor.authorBan, Mariaen_US
dc.contributor.authorOksenberg, Jorge Ren_US
dc.contributor.authorHintzen, Rogieren_US
dc.contributor.authorBarcellos, Lisa Fen_US
dc.contributor.authorAgliardi, Cristinaen_US
dc.contributor.authorAlfredsson, Larsen_US
dc.contributor.authorAlizadeh, Mehdien_US
dc.contributor.authorAnderson, Carlen_US
dc.contributor.authorAndrews, Roberten_US
dc.contributor.authorSøndergaard, Helle Bachen_US
dc.contributor.authorBaker, Amieen_US
dc.contributor.authorBand, Gavinen_US
dc.contributor.authorBaranzini, Sergio Een_US
dc.contributor.authorBarizzone, Nadiaen_US
dc.contributor.authorBarrett, Jeffreyen_US
dc.contributor.authorBellenguez, Célineen_US
dc.contributor.authorBergamaschi, Lauraen_US
dc.contributor.authorBernardinelli, Luisaen_US
dc.contributor.authorBerthele, Achimen_US
dc.contributor.authorBiberacher, Violaen_US
dc.contributor.authorBinder, Thomas M Cen_US
dc.contributor.authorBlackburn, Hannahen_US
dc.contributor.authorBomfim, Izaura Len_US
dc.contributor.authorBrambilla, Paolaen_US
dc.contributor.authorBroadley, Simonen_US
dc.contributor.authorBrochet, Brunoen_US
dc.contributor.authorBrundin, Louen_US
dc.contributor.authorBuck, Dorotheaen_US
dc.contributor.authorButzkueven, Helmuten_US
dc.contributor.authorCaillier, Stacy Jen_US
dc.contributor.authorCamu, Williamen_US
dc.contributor.authorCarpentier, Wassilaen_US
dc.contributor.authorCavalla, Paolaen_US
dc.contributor.authorCelius, Elisabeth Gen_US
dc.contributor.authorComan, Irèneen_US
dc.contributor.authorComi, Giancarloen_US
dc.contributor.authorCorrado, Luciaen_US
dc.contributor.authorCosemans, Leentjeen_US
dc.contributor.authorCournu-Rebeix, Isabelleen_US
dc.contributor.authorCree, Bruce A Cen_US
dc.contributor.authorCusi, Danieleen_US
dc.contributor.authorDamotte, Vincenten_US
dc.contributor.authorDefer, Gillesen_US
dc.contributor.authorDelgado, Silvia Ren_US
dc.contributor.authorDeloukas, Panosen_US
dc.contributor.authordi Sapio, Alessiaen_US
dc.contributor.authorDilthey, Alexander Ten_US
dc.contributor.authorDonnelly, Peteren_US
dc.contributor.authorDubois, Bénédicteen_US
dc.contributor.authorDuddy, Martinen_US
dc.contributor.authorEdkins, Sarahen_US
dc.contributor.authorElovaara, Irinaen_US
dc.contributor.authorEsposito, Federicaen_US
dc.contributor.authorEvangelou, Nikosen_US
dc.contributor.authorFiddes, Barnabyen_US
dc.contributor.authorField, Judithen_US
dc.contributor.authorFranke, Andreen_US
dc.contributor.authorFreeman, Colinen_US
dc.contributor.authorFrohlich, Irene Yen_US
dc.contributor.authorGalimberti, Danielaen_US
dc.contributor.authorGieger, Christianen_US
dc.contributor.authorGourraud, Pierre-Antoineen_US
dc.contributor.authorGraetz, Christianeen_US
dc.contributor.authorGraham, Andrewen_US
dc.contributor.authorGrummel, Verenaen_US
dc.contributor.authorGuaschino, Claraen_US
dc.contributor.authorHadjixenofontos, Athenaen_US
dc.contributor.authorHakonarson, Hakonen_US
dc.contributor.authorHalfpenny, Christopheren_US
dc.contributor.authorHall, Gillianen_US
dc.contributor.authorHall, Peren_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorHarley, Jamesen_US
dc.contributor.authorHarrower, Timothyen_US
dc.contributor.authorHawkins, Cliveen_US
dc.contributor.authorHellenthal, Garretten_US
dc.contributor.authorHillier, Charlesen_US
dc.contributor.authorHobart, Jeremyen_US
dc.contributor.authorHoshi, Munien_US
dc.contributor.authorHunt, Sarah Een_US
dc.contributor.authorJagodic, Majaen_US
dc.contributor.authorJelčić, Ilijasen_US
dc.contributor.authorJochim, Angelaen_US
dc.contributor.authorKendall, Brianen_US
dc.contributor.authorKermode, Allanen_US
dc.contributor.authorKilpatrick, Trevoren_US
dc.contributor.authorKoivisto, Keijoen_US
dc.contributor.authorKonidari, Ioannaen_US
dc.contributor.authorKorn, Thomasen_US
dc.contributor.authorKronsbein, Helenaen_US
dc.contributor.authorLangford, Cordeliaen_US
dc.contributor.authorLarsson, Malinen_US
dc.contributor.authorLathrop, Marken_US
dc.contributor.authorLebrun-Frenay, Christineen_US
dc.contributor.authorLechner-Scott, Jeannetteen_US
dc.contributor.authorLee, Michelle Hen_US
dc.contributor.authorLeone, Maurizio Aen_US
dc.contributor.authorLeppä, Virpien_US
dc.contributor.authorLiberatore, Giuseppeen_US
dc.contributor.authorLie, Benedicte Aen_US
dc.contributor.authorLill, Christina Men_US
dc.contributor.authorLindén, Magdalenaen_US
dc.contributor.authorLink, Jennyen_US
dc.contributor.authorLuessi, Felixen_US
dc.contributor.authorLycke, Janen_US
dc.contributor.authorMacciardi, Fabioen_US
dc.contributor.authorMännistö, Satuen_US
dc.contributor.authorManrique, Clara Pen_US
dc.contributor.authorMartin, Rolanden_US
dc.contributor.authorMartinelli, Vittorioen_US
dc.contributor.authorMason, Deborahen_US
dc.contributor.authorMazibrada, Gordonen_US
dc.contributor.authorMcCabe, Cristinen_US
dc.contributor.authorMero, Inger-Liseen_US
dc.contributor.authorMescheriakova, Juliaen_US
dc.contributor.authorMoutsianas, Loukasen_US
dc.contributor.authorMyhr, Kjell-Mortenen_US
dc.contributor.authorNagels, Guyen_US
dc.contributor.authorNicholas, Richarden_US
dc.contributor.authorNilsson, Petraen_US
dc.contributor.authorPiehl, Fredriken_US
dc.contributor.authorPirinen, Mattien_US
dc.contributor.authorPrice, Siân Een_US
dc.contributor.authorQuach, Hongen_US
dc.contributor.authorReunanen, Maurien_US
dc.contributor.authorRobberecht, Wimen_US
dc.contributor.authorRobertson, Neil Pen_US
dc.contributor.authorRodegher, Mariaemmaen_US
dc.contributor.authorRog, Daviden_US
dc.contributor.authorSalvetti, Marcoen_US
dc.contributor.authorSchnetz-Boutaud, Nathalie Cen_US
dc.contributor.authorSellebjerg, Finnen_US
dc.contributor.authorSelter, Rebecca Cen_US
dc.contributor.authorSchaefer, Catherineen_US
dc.contributor.authorShaunak, Sandipen_US
dc.contributor.authorShen, Lingen_US
dc.contributor.authorShields, Simonen_US
dc.contributor.authorSiffrin, Volkeren_US
dc.contributor.authorSlee, Marken_US
dc.contributor.authorSorensen, Per Soelbergen_US
dc.contributor.authorSorosina, Melissaen_US
dc.contributor.authorSospedra, Mireiaen_US
dc.contributor.authorSpurkland, Anneen_US
dc.contributor.authorStrange, Amyen_US
dc.contributor.authorSundqvist, Emilieen_US
dc.contributor.authorThijs, Vincenten_US
dc.contributor.authorThorpe, Johnen_US
dc.contributor.authorTicca, Annaen_US
dc.contributor.authorTienari, Penttien_US
dc.contributor.authorvan Duijn, Corneliaen_US
dc.contributor.authorVisser, Elizabeth Men_US
dc.contributor.authorVucic, Steveen_US
dc.contributor.authorWesterlind, Helgaen_US
dc.contributor.authorWiley, James Sen_US
dc.contributor.authorWilkins, Alastairen_US
dc.contributor.authorWilson, James Fen_US
dc.contributor.authorWinkelmann, Julianeen_US
dc.contributor.authorZajicek, Johnen_US
dc.contributor.authorZindler, Evaen_US
dc.contributor.authorHaines, Jonathan Len_US
dc.contributor.authorPericak-Vance, Margaret Aen_US
dc.contributor.authorIvinson, Adrian Jen_US
dc.contributor.authorStewart, Graemeen_US
dc.contributor.authorHafler, Daviden_US
dc.contributor.authorHauser, Stephen Len_US
dc.contributor.authorCompston, Alastairen_US
dc.contributor.authorMcVean, Gilen_US
dc.contributor.authorDe Jager, Philipen_US
dc.contributor.authorSawcer, Stephenen_US
dc.contributor.authorMcCauley, Jacob Len_US
dc.date.accessioned2014-07-07T18:14:37Z
dc.date.issued2013en_US
dc.identifier.citationBeecham, A. H., N. A. Patsopoulos, D. K. Xifara, M. F. Davis, A. Kemppinen, C. Cotsapas, T. S. Shahi, et al. 2013. “Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.” Nature genetics 45 (11): 10.1038/ng.2770. doi:10.1038/ng.2770. http://dx.doi.org/10.1038/ng.2770.en
dc.identifier.issn1061-4036en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406971
dc.description.abstractUsing the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 × 10-4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 multiple sclerosis subjects and 26,703 healthy controls. In these 80,094 individuals of European ancestry we identified 48 new susceptibility variants (p-value < 5.0 × 10-8); three found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants in 103 discrete loci outside of the Major Histocompatibility Complex. With high resolution Bayesian fine-mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalogue of multiple sclerosis risk variants and illustrates the value of fine-mapping in the resolution of GWAS signals.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ng.2770en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895/pdf/en
dash.licenseLAAen_US
dc.titleAnalysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature geneticsen
dash.depositing.authorPatsopoulos, Nikolaos Aen_US
dc.date.available2014-07-07T18:14:37Z
dc.identifier.doi10.1038/ng.2770*
dash.authorsorderedfalse
dash.contributor.affiliatedPatsopoulos, Nikolaos
dash.contributor.affiliatedIvinson, Adrian
dash.contributor.affiliatedDe Jager, Philip


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