Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

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Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

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dc.contributor.author Beecham, Ashley H en_US
dc.contributor.author Patsopoulos, Nikolaos A en_US
dc.contributor.author Xifara, Dionysia K en_US
dc.contributor.author Davis, Mary F en_US
dc.contributor.author Kemppinen, Anu en_US
dc.contributor.author Cotsapas, Chris en_US
dc.contributor.author Shahi, Tejas S en_US
dc.contributor.author Spencer, Chris en_US
dc.contributor.author Booth, David en_US
dc.contributor.author Goris, An en_US
dc.contributor.author Oturai, Annette en_US
dc.contributor.author Saarela, Janna en_US
dc.contributor.author Fontaine, Bertrand en_US
dc.contributor.author Hemmer, Bernhard en_US
dc.contributor.author Martin, Claes en_US
dc.contributor.author Zipp, Frauke en_US
dc.contributor.author D’alfonso, Sandra en_US
dc.contributor.author Martinelli-Boneschi, Filippo en_US
dc.contributor.author Taylor, Bruce en_US
dc.contributor.author Harbo, Hanne F en_US
dc.contributor.author Kockum, Ingrid en_US
dc.contributor.author Hillert, Jan en_US
dc.contributor.author Olsson, Tomas en_US
dc.contributor.author Ban, Maria en_US
dc.contributor.author Oksenberg, Jorge R en_US
dc.contributor.author Hintzen, Rogier en_US
dc.contributor.author Barcellos, Lisa F en_US
dc.contributor.author Agliardi, Cristina en_US
dc.contributor.author Alfredsson, Lars en_US
dc.contributor.author Alizadeh, Mehdi en_US
dc.contributor.author Anderson, Carl en_US
dc.contributor.author Andrews, Robert en_US
dc.contributor.author Søndergaard, Helle Bach en_US
dc.contributor.author Baker, Amie en_US
dc.contributor.author Band, Gavin en_US
dc.contributor.author Baranzini, Sergio E en_US
dc.contributor.author Barizzone, Nadia en_US
dc.contributor.author Barrett, Jeffrey en_US
dc.contributor.author Bellenguez, Céline en_US
dc.contributor.author Bergamaschi, Laura en_US
dc.contributor.author Bernardinelli, Luisa en_US
dc.contributor.author Berthele, Achim en_US
dc.contributor.author Biberacher, Viola en_US
dc.contributor.author Binder, Thomas M C en_US
dc.contributor.author Blackburn, Hannah en_US
dc.contributor.author Bomfim, Izaura L en_US
dc.contributor.author Brambilla, Paola en_US
dc.contributor.author Broadley, Simon en_US
dc.contributor.author Brochet, Bruno en_US
dc.contributor.author Brundin, Lou en_US
dc.contributor.author Buck, Dorothea en_US
dc.contributor.author Butzkueven, Helmut en_US
dc.contributor.author Caillier, Stacy J en_US
dc.contributor.author Camu, William en_US
dc.contributor.author Carpentier, Wassila en_US
dc.contributor.author Cavalla, Paola en_US
dc.contributor.author Celius, Elisabeth G en_US
dc.contributor.author Coman, Irène en_US
dc.contributor.author Comi, Giancarlo en_US
dc.contributor.author Corrado, Lucia en_US
dc.contributor.author Cosemans, Leentje en_US
dc.contributor.author Cournu-Rebeix, Isabelle en_US
dc.contributor.author Cree, Bruce A C en_US
dc.contributor.author Cusi, Daniele en_US
dc.contributor.author Damotte, Vincent en_US
dc.contributor.author Defer, Gilles en_US
dc.contributor.author Delgado, Silvia R en_US
dc.contributor.author Deloukas, Panos en_US
dc.contributor.author di Sapio, Alessia en_US
dc.contributor.author Dilthey, Alexander T en_US
dc.contributor.author Donnelly, Peter en_US
dc.contributor.author Dubois, Bénédicte en_US
dc.contributor.author Duddy, Martin en_US
dc.contributor.author Edkins, Sarah en_US
dc.contributor.author Elovaara, Irina en_US
dc.contributor.author Esposito, Federica en_US
dc.contributor.author Evangelou, Nikos en_US
dc.contributor.author Fiddes, Barnaby en_US
dc.contributor.author Field, Judith en_US
dc.contributor.author Franke, Andre en_US
dc.contributor.author Freeman, Colin en_US
dc.contributor.author Frohlich, Irene Y en_US
dc.contributor.author Galimberti, Daniela en_US
dc.contributor.author Gieger, Christian en_US
dc.contributor.author Gourraud, Pierre-Antoine en_US
dc.contributor.author Graetz, Christiane en_US
dc.contributor.author Graham, Andrew en_US
dc.contributor.author Grummel, Verena en_US
dc.contributor.author Guaschino, Clara en_US
dc.contributor.author Hadjixenofontos, Athena en_US
dc.contributor.author Hakonarson, Hakon en_US
dc.contributor.author Halfpenny, Christopher en_US
dc.contributor.author Hall, Gillian en_US
dc.contributor.author Hall, Per en_US
dc.contributor.author Hamsten, Anders en_US
dc.contributor.author Harley, James en_US
dc.contributor.author Harrower, Timothy en_US
dc.contributor.author Hawkins, Clive en_US
dc.contributor.author Hellenthal, Garrett en_US
dc.contributor.author Hillier, Charles en_US
dc.contributor.author Hobart, Jeremy en_US
dc.contributor.author Hoshi, Muni en_US
dc.contributor.author Hunt, Sarah E en_US
dc.contributor.author Jagodic, Maja en_US
dc.contributor.author Jelčić, Ilijas en_US
dc.contributor.author Jochim, Angela en_US
dc.contributor.author Kendall, Brian en_US
dc.contributor.author Kermode, Allan en_US
dc.contributor.author Kilpatrick, Trevor en_US
dc.contributor.author Koivisto, Keijo en_US
dc.contributor.author Konidari, Ioanna en_US
dc.contributor.author Korn, Thomas en_US
dc.contributor.author Kronsbein, Helena en_US
dc.contributor.author Langford, Cordelia en_US
dc.contributor.author Larsson, Malin en_US
dc.contributor.author Lathrop, Mark en_US
dc.contributor.author Lebrun-Frenay, Christine en_US
dc.contributor.author Lechner-Scott, Jeannette en_US
dc.contributor.author Lee, Michelle H en_US
dc.contributor.author Leone, Maurizio A en_US
dc.contributor.author Leppä, Virpi en_US
dc.contributor.author Liberatore, Giuseppe en_US
dc.contributor.author Lie, Benedicte A en_US
dc.contributor.author Lill, Christina M en_US
dc.contributor.author Lindén, Magdalena en_US
dc.contributor.author Link, Jenny en_US
dc.contributor.author Luessi, Felix en_US
dc.contributor.author Lycke, Jan en_US
dc.contributor.author Macciardi, Fabio en_US
dc.contributor.author Männistö, Satu en_US
dc.contributor.author Manrique, Clara P en_US
dc.contributor.author Martin, Roland en_US
dc.contributor.author Martinelli, Vittorio en_US
dc.contributor.author Mason, Deborah en_US
dc.contributor.author Mazibrada, Gordon en_US
dc.contributor.author McCabe, Cristin en_US
dc.contributor.author Mero, Inger-Lise en_US
dc.contributor.author Mescheriakova, Julia en_US
dc.contributor.author Moutsianas, Loukas en_US
dc.contributor.author Myhr, Kjell-Morten en_US
dc.contributor.author Nagels, Guy en_US
dc.contributor.author Nicholas, Richard en_US
dc.contributor.author Nilsson, Petra en_US
dc.contributor.author Piehl, Fredrik en_US
dc.contributor.author Pirinen, Matti en_US
dc.contributor.author Price, Siân E en_US
dc.contributor.author Quach, Hong en_US
dc.contributor.author Reunanen, Mauri en_US
dc.contributor.author Robberecht, Wim en_US
dc.contributor.author Robertson, Neil P en_US
dc.contributor.author Rodegher, Mariaemma en_US
dc.contributor.author Rog, David en_US
dc.contributor.author Salvetti, Marco en_US
dc.contributor.author Schnetz-Boutaud, Nathalie C en_US
dc.contributor.author Sellebjerg, Finn en_US
dc.contributor.author Selter, Rebecca C en_US
dc.contributor.author Schaefer, Catherine en_US
dc.contributor.author Shaunak, Sandip en_US
dc.contributor.author Shen, Ling en_US
dc.contributor.author Shields, Simon en_US
dc.contributor.author Siffrin, Volker en_US
dc.contributor.author Slee, Mark en_US
dc.contributor.author Sorensen, Per Soelberg en_US
dc.contributor.author Sorosina, Melissa en_US
dc.contributor.author Sospedra, Mireia en_US
dc.contributor.author Spurkland, Anne en_US
dc.contributor.author Strange, Amy en_US
dc.contributor.author Sundqvist, Emilie en_US
dc.contributor.author Thijs, Vincent en_US
dc.contributor.author Thorpe, John en_US
dc.contributor.author Ticca, Anna en_US
dc.contributor.author Tienari, Pentti en_US
dc.contributor.author van Duijn, Cornelia en_US
dc.contributor.author Visser, Elizabeth M en_US
dc.contributor.author Vucic, Steve en_US
dc.contributor.author Westerlind, Helga en_US
dc.contributor.author Wiley, James S en_US
dc.contributor.author Wilkins, Alastair en_US
dc.contributor.author Wilson, James F en_US
dc.contributor.author Winkelmann, Juliane en_US
dc.contributor.author Zajicek, John en_US
dc.contributor.author Zindler, Eva en_US
dc.contributor.author Haines, Jonathan L en_US
dc.contributor.author Pericak-Vance, Margaret A en_US
dc.contributor.author Ivinson, Adrian J en_US
dc.contributor.author Stewart, Graeme en_US
dc.contributor.author Hafler, David en_US
dc.contributor.author Hauser, Stephen L en_US
dc.contributor.author Compston, Alastair en_US
dc.contributor.author McVean, Gil en_US
dc.contributor.author De Jager, Philip en_US
dc.contributor.author Sawcer, Stephen en_US
dc.contributor.author McCauley, Jacob L en_US
dc.date.accessioned 2014-07-07T18:14:37Z
dc.date.issued 2013 en_US
dc.identifier.citation Beecham, A. H., N. A. Patsopoulos, D. K. Xifara, M. F. Davis, A. Kemppinen, C. Cotsapas, T. S. Shahi, et al. 2013. “Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.” Nature genetics 45 (11): 10.1038/ng.2770. doi:10.1038/ng.2770. http://dx.doi.org/10.1038/ng.2770. en
dc.identifier.issn 1061-4036 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406971
dc.description.abstract Using the ImmunoChip custom genotyping array, we analysed 14,498 multiple sclerosis subjects and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (p-value < 1.0 × 10-4). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 multiple sclerosis subjects and 26,703 healthy controls. In these 80,094 individuals of European ancestry we identified 48 new susceptibility variants (p-value < 5.0 × 10-8); three found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants in 103 discrete loci outside of the Major Histocompatibility Complex. With high resolution Bayesian fine-mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalogue of multiple sclerosis risk variants and illustrates the value of fine-mapping in the resolution of GWAS signals. en
dc.language.iso en_US en
dc.relation.isversionof doi:10.1038/ng.2770 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895/pdf/ en
dash.license LAA en_US
dc.title Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Nature genetics en
dash.depositing.author Patsopoulos, Nikolaos A en_US
dc.date.available 2014-07-07T18:14:37Z

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