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dc.contributor.authorYu, Xiaocongen_US
dc.contributor.authorLi, Zihaien_US
dc.contributor.authorZhou, Zhenxianen_US
dc.contributor.authorKilby, J Michaelen_US
dc.contributor.authorJiang, Weien_US
dc.date.accessioned2014-07-07T18:15:03Z
dc.date.issued2013en_US
dc.identifier.citationYu, Xiaocong, Zihai Li, Zhenxian Zhou, J Michael Kilby, and Wei Jiang. 2013. “Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease.” Epidemiology (Sunnyvale, Calif.) 3 (1): 120. doi:10.4172/2161-1165.1000120. http://dx.doi.org/10.4172/2161-1165.1000120.en
dc.identifier.issn2161-1165en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12407026
dc.description.abstractAlthough T cells are the primary and most-studied targets of the Human Immunodeficiency Virus (HIV), B cells, especially memory B lymphocytes, are also chronically depleted in the course of HIV disease. Although the lack of CD4+ T cell help may explain these deficiencies, intrinsic defects in B lymphocytes appear to contribute to B cell depletion and reduced antibody (Ab) production in the setting of HIV, especially of some antigens eliciting T cell-independent responses. The gut mucosal barrier is disrupted in HIV disease, resulting in increased systemic exposure to microbial products such as Toll-Like Receptor (TLR) agonists. The association of enhanced systemic levels of TLR agonists and B cell dysfunction in HIV disease is not understood. This review discusses the potential role of microbial TLR agonists in the B cell depletion, enhanced autoantibody production and impaired responses to vaccination observed in HIV-infected hosts. Increased microbial translocation in HIV infection may drive B cells to produce autoantibodies and increase susceptibilities of B cells to apoptosis through activation-induced cell death. Determining the mechanisms of B cell perturbations in HIV disease will inform the design of novel strategies of improve immune responses to vaccines, reduce opportunistic infections and slow disease progression.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.4172/2161-1165.1000120en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005894/pdf/en
dash.licenseLAAen_US
dc.subjectAntibodyen
dc.subjectToll-like receptoren
dc.subjectHuman Immunodeficiency Virus (HIV)en
dc.titleMicrobial TLR Agonists and Humoral Immunopathogenesis in HIV Diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalEpidemiology (Sunnyvale, Calif.)en
dash.depositing.authorYu, Xiaocongen_US
dc.date.available2014-07-07T18:15:03Z
dc.identifier.doi10.4172/2161-1165.1000120*
dash.contributor.affiliatedYu, Xiaocong


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