What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

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What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

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Title: What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
Author: Perálvarez-Marín, Alex; Doñate-Macian, Pau; Gaudet, Rachelle

Note: Order does not necessarily reflect citation order of authors.

Citation: Perálvarez-Marín, Alex, Pau Doñate-Macian, and Rachelle Gaudet. 2013. “What Do We Know About the Transient Receptor Potential Vanilloid 2 (TRPV2) Ion Channel?” FEBS J 280 (21) (November): 5471–5487.
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Abstract: Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily (TRPV) named after the vanilloid receptor 1 (TRPV1) consists of six members, and at least four of them (TRPV1–TRPV4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV2 in an attempt to shed some light on the physiological and pharmacological deorphanization of TRPV2.
Published Version: doi:10.1111/febs.12302
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12410513
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