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dc.contributor.authorFarris, Alton B.
dc.contributor.authorDemicco, Elizabeth G.
dc.contributor.authorLe, Long Phi
dc.contributor.authorFinberg, Karin E.
dc.contributor.authorMiller, Julie
dc.contributor.authorMandal, Rajni
dc.contributor.authorFukuoka, Junya
dc.contributor.authorCohen, Cynthia
dc.contributor.authorGaissert, Henning Arthur
dc.contributor.authorZukerberg, Lawrence R.
dc.contributor.authorLauwers, Gregory Y.
dc.contributor.authorIafrate, Anthony John
dc.contributor.authorMino-Kenudson, Mari
dc.date.accessioned2014-07-14T03:18:55Z
dc.date.issued2011
dc.identifier.citationFarris, Alton B., Elizabeth G. Demicco, Long Phe Le, Karin E. Finberg, Julie Miller, Rajni Mandal, Junya Fukuoka, et al. 2011. Clinicopathologic and molecular profiles of microsatellite unstable Barrett esophagus-associated adenocarcinoma. The American Journal of Surgical Pathology 35(5): 647–655.en_US
dc.identifier.issn0147-5185en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12490654
dc.description.abstractMicrosatellite instability (MSI) has been reported in various tumors, with colon cancer as the prototype. However, little is known about MSI in Barrett esophagus (BE)-associated adenocarcinoma. Thus, the aim of this study was to compare the clinicopathologic and molecular features of BE-associated adenocarcinomas with and without MSI. The study cohort consisted of 76 patients with BE-associated adenocarcinomas (66 male, 10 female), with a mean age of 65.1 years. Immunohistochemistry (IHC) for MLH1, MSH2, MSH6, PMS2, and CD3 and in situ hybridization for Epstein-Barr virus-encoded RNA were performed. MLH1 and PMS2 expression was lost by IHC in 5 cases (6.6%); of these, 5 showed high-level MSI (MSI-H) by polymerase chain reaction assay, and 4 showed hMLH1 promoter methylation. Histologically, tumors with MSI-H were heterogenous and included conventional adenocarcinomas with tumor-infiltrating lymphocytes (n=1), medullary carcinoma (n=2), signet ring cells (n=1), and signet ring cell and mucinous components (n=1). Compared with tumors negative for MSI by IHC, BE-associated adenocarcinomas with MSI-H were associated with older patient age (P=0.0060), lymphovascular invasion (P=0.027), and significantly larger numbers of tumor-infiltrating lymphocytes (P<0.0001). However, there was no statistical difference in overall survival between the 2 groups (P=0.285). In conclusion, MSI-H is uncommon in BE-associated adenocarcinomas, but is associated with clinicopathologic features fairly similar to sporadic microsatellite unstable colorectal cancers. Given the growing evidence that indicates lack of benefits from adjuvant therapy with fluorouracil in the colonic counterpart, it may be important to identify MSI-H in BE-associated adenocarcinomas.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1097/PAS.0b013e31820f18a2en_US
dash.licenseLAA
dc.subjectBarrett esophagusen_US
dc.subjectesophageal adenocarcinomaen_US
dc.subjectmicrosatellite instabilityen_US
dc.subjecthistologyen_US
dc.subjectmedullary carcinomaen_US
dc.subjecttumor-infiltrating lymphocyteen_US
dc.titleClinicopathologic and Molecular Profiles of Microsatellite Unstable Barrett Esophagus-associated Adenocarcinomaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe American Journal of Surgical Pathologyen_US
dash.depositing.authorLauwers, Gregory Y.
dc.date.available2014-07-14T03:18:55Z
dc.identifier.doi10.1097/PAS.0b013e31820f18a2*
dash.authorsorderedfalse
dash.contributor.affiliatedZukerberg, Lawrence
dash.contributor.affiliatedGaissert, Henning
dash.contributor.affiliatedIafrate, Anthony
dash.contributor.affiliatedLe, Long Phi
dash.contributor.affiliatedMino-Kenudson, Mari
dash.contributor.affiliatedLauwers, Gregory Y.


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