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dc.contributor.authorFritz, Stefan
dc.contributor.authorFernandez-Del Castillo, Carlos F.
dc.contributor.authorMino-Kenudson, Mari
dc.contributor.authorCrippa, Stefano
dc.contributor.authorDeshpande, Vikram
dc.contributor.authorLauwers, Gregory Y.
dc.contributor.authorWarshaw, Andrew Louis
dc.contributor.authorThayer, Sarah P.
dc.contributor.authorIafrate, Anthony John
dc.date.accessioned2014-07-29T16:05:14Z
dc.date.issued2009
dc.identifier.citationFritz, Stefan, Carlos Fernandez-del Castillo, Mari Mino-Kenudson, Stefano Crippa, Vikram Deshpande, Gregory Y. Lauwers, Andrew L. Warshaw, Sarah P. Thayer, and A John Iafrate. 2009. Global genomic analysis of intraductal papillary mucinous neoplasms of the pancreas reveals significant molecular differences compared to ductal adenocarcinoma. Annals of Surgery 249(3): 440–447.en_US
dc.identifier.issn0003-4932en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12601520
dc.description.abstractObjective: To determine whether intraductal papillary mucinous neoplasms of the pancreas (IPMNs) have a different genetic background compared with ductal adenocarcinoma (PDAC). Summary Background Data: The biologic and clinical behavior of IPMNs and IPMN-associated adenocarcinomas is different from PDAC in having a less aggressive tumor growth and significantly improved survival. Up to date, the molecular mechanisms underlying the clinical behavior of IPMNs are incompletely understood. Methods: 128 cystic pancreatic lesions were prospectively identified during the course of 2 years. From the corresponding surgical specimens, 57 IPMNs were separated and subdivided by histologic criteria into those with low-grade dysplasia, moderate dysplasia, high-grade dysplasia, and invasive cancer. Twenty specimens were suitable for DNA isolation and subsequent performance of array CGH. Results: While none of the IPMNs with low-grade dysplasia displayed detectable chromosomal aberrations, IPMNs with moderate and high-grade dysplasia showed frequent copy number alterations. Commonly lost regions were located on chromosome 5q, 6q, 10q, 11q, 13q, 18q, and 22q. The incidence of loss of chromosome 5q, 6q, and 11q was significantly higher in IPMNs with high-grade dysplasia or invasion compared with PDAC. Ten of 13 IPMNs with moderate dysplasia or malignancy had loss of part or all of chromosome 6q, with a minimal deleted region between linear positions 78.0 and 130.0. Conclusions: This study is the first to use array CGH to characterize IPMNs. Recurrent cytogenetic alterations were identified and were different than those described in PDAC. Array CGH may help distinguish between these 2 entities and give insight into the differences in their biology and prognosis.en_US
dc.language.isoen_USen_US
dc.publisherOvid Technologies (Wolters Kluwer Health)en_US
dc.relation.isversionofdoi:10.1097/sla.0b013e31819a6e16en_US
dash.licenseLAA
dc.subjectintraductal papillary mucinous neoplasmsen_US
dc.subjectcomparative genomic hybridizationen_US
dc.subjectgenetic characterizationen_US
dc.subjectchromosomal aberrationsen_US
dc.subjectKRASen_US
dc.titleGlobal Genomic Analysis of Intraductal Papillary Mucinous Neoplasms of the Pancreas Reveals Significant Molecular Differences Compared to Ductal Adenocarcinomaen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalAnnals of Surgeryen_US
dash.depositing.authorLauwers, Gregory Y.
dc.date.available2014-07-29T16:05:14Z
dc.identifier.doi10.1097/sla.0b013e31819a6e16*
workflow.legacycommentsPer Sherpa can post manuscript after embargo, which has long since expired.en_US
dash.authorsorderedfalse
dash.contributor.affiliatedWarshaw, Andrew
dash.contributor.affiliatedThayer, Sarah P.
dash.contributor.affiliatedLauwers, Gregory Y.
dash.contributor.affiliatedDeshpande, Vikram
dash.contributor.affiliatedFernandez-Del Castillo, Carlos
dash.contributor.affiliatedIafrate, Anthony
dash.contributor.affiliatedMino-Kenudson, Mari
dc.identifier.orcid0000-0003-4230-9308


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