dc.contributor.author | Evans, John A. | |
dc.contributor.author | Bouma, Brett | |
dc.contributor.author | Bressner, Jason | |
dc.contributor.author | Shishkov, Milen Stefanov | |
dc.contributor.author | Lauwers, Gregory Y. | |
dc.contributor.author | Mino-Kenudson, Mari | |
dc.contributor.author | Nishioka, Norman Shizuaki | |
dc.contributor.author | Tearney, Guillermo James | |
dc.date.accessioned | 2014-07-29T16:21:53Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Evans, John A., Brett E. Bouma, Jason Bressner, Milen Shishkov, Gregory Y. Lauwers, Mari Mino-Kenudson, Norman S. Nishioka, and Guillermo J. Tearney. 2007. Identifying intestinal metaplasia at the squamocolumnar junction by using optical coherence tomography. Gastrointestinal Endoscopy 65(1): 50–56. | en_US |
dc.identifier.issn | 0016-5107 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:12601540 | |
dc.description.abstract | Background: Optical coherence tomography (OCT) is an optical imaging method that produces high-resolution cross-sectional images of the esophagus. The accuracy of OCT for differentiating tissue types at the squamocolumnar junction (SCJ) has not been established. Objective: The purpose of this study was to identify and validate OCT image criteria for distinguishing metaplastic from nonmetaplastic tissue at the SCJ. Design: A total of 196 biopsy-correlated OCT images of the SCJ were acquired from 113 patients undergoing upper endoscopy. A pathologist blinded to the OCT results reviewed each pathology specimen and determined the presence of the following histopathology: gastric cardia, squamous mucosa, pancreatic metaplasia, and intestinal metaplasia. An algorithm for diagnosing specialized intestinal metaplasia (SIM) was created by reviewing a training set of 40 biopsy-correlated OCT images. Two blinded investigators prospectively tested the algorithm on a validation set of 123 images. Results: OCT images of squamous mucosa were characterized by a layered appearance without epithelial glands; gastric cardia, by vertical pit and gland structure, a well-defined epithelial surface reflectivity, and relatively poor image penetration; and SIM by an irregular architecture and good image penetration. The OCT criteria were 85% sensitive and 95% specific for SIM when applied retrospectively to the training set. When applied to the validation set, the algorithm was 81% sensitive for both OCT readers and 66% and 57% specific for diagnosing SIM. The interobserver agreement was good (κ = 0.53). Conclusions: OCT imaging can identify SIM at the SCJ with an accuracy similar to that of endoscopy. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier BV | en_US |
dc.relation.isversionof | doi:10.1016/j.gie.2006.04.027 | en_US |
dash.license | LAA | |
dc.title | Identifying Intestinal Metaplasia at the Squamocolumnar Junction by Using Optical Coherence Tomography | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Gastrointestinal Endoscopy | en_US |
dash.depositing.author | Lauwers, Gregory Y. | |
dc.date.available | 2014-07-29T16:21:53Z | |
dc.identifier.doi | 10.1016/j.gie.2006.04.027 | * |
dash.contributor.affiliated | Shishkov, Milen | |
dash.contributor.affiliated | Nishioka, Norman | |
dash.contributor.affiliated | Tearney, Guillermo | |
dash.contributor.affiliated | Lauwers, Gregory Y. | |
dash.contributor.affiliated | Bouma, Brett | |
dash.contributor.affiliated | Mino-Kenudson, Mari | |