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dc.contributor.authorButovsky, Olegen_US
dc.contributor.authorJedrychowski, Mark P.en_US
dc.contributor.authorMoore, Craig S.en_US
dc.contributor.authorCialic, Ronen_US
dc.contributor.authorLanser, Amanda J.en_US
dc.contributor.authorGabriely, Galinaen_US
dc.contributor.authorKoeglsperger, Thomasen_US
dc.contributor.authorDake, Benen_US
dc.contributor.authorWu, Pauline M.en_US
dc.contributor.authorDoykan, Camille E.en_US
dc.contributor.authorFanek, Zainen_US
dc.contributor.authorLiu, LiPingen_US
dc.contributor.authorChen, Zhuoxunen_US
dc.contributor.authorRothstein, Jeffrey D.en_US
dc.contributor.authorRansohoff, Richard M.en_US
dc.contributor.authorGygi, Steven P.en_US
dc.contributor.authorAntel, Jack P.en_US
dc.contributor.authorWeiner, Howard L.en_US
dc.date.accessioned2014-08-13T13:58:04Z
dc.date.issued2014en_US
dc.identifier.citationButovsky, O., M. P. Jedrychowski, C. S. Moore, R. Cialic, A. J. Lanser, G. Gabriely, T. Koeglsperger, et al. 2014. “Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia.” Nature neuroscience 17 (1): 131-143. doi:10.1038/nn.3599. http://dx.doi.org/10.1038/nn.3599.en
dc.identifier.issn1097-6256en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717374
dc.description.abstractMicroglia are myeloid cells of the central nervous system (CNS) that participate both in normal CNS function and disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia vs. myeloid and other immune cells. Out of 239 genes, 106 were enriched in microglia as compared to astrocytes, oligodendrocytes and neurons. This microglia signature was not observed in microglial lines or in monocytes recruited to the CNS and was also observed in human microglia. Based on this signature, we found a crucial role for TGF-β in microglial biology that included: 1) the requirement of TGF-β for the in vitro development of microglia that express the microglial molecular signature characteristic of adult microglia; and 2) the absence of microglia in CNS TGF-β1 deficient mice. Our results identify a unique microglial signature that is dependent on TGF-β signaling which provides insights into microglial biology and the possibility of targeting microglia for the treatment of CNS disease.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nn.3599en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066672/pdf/en
dash.licenseLAAen_US
dc.titleIdentification of a Unique TGF-β Dependent Molecular and Functional Signature in Microgliaen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature neuroscienceen
dash.depositing.authorButovsky, Olegen_US
dc.date.available2014-08-13T13:58:04Z
dc.identifier.doi10.1038/nn.3599*
dash.authorsorderedfalse
dash.contributor.affiliatedLanser, Amanda J.
dash.contributor.affiliatedCialic, Ron
dash.contributor.affiliatedButovsky, Oleg
dash.contributor.affiliatedGabriely, Galina
dash.contributor.affiliatedWeiner, Howard
dash.contributor.affiliatedJedrychowski, Mark
dash.contributor.affiliatedGygi, Steven
dc.identifier.orcid0000-0003-0203-9681


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