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dc.contributor.authorHolmes, Michael Ven_US
dc.contributor.authorDale, Caroline Een_US
dc.contributor.authorZuccolo, Luisaen_US
dc.contributor.authorSilverwood, Richard Jen_US
dc.contributor.authorGuo, Yiranen_US
dc.contributor.authorYe, Zhengen_US
dc.contributor.authorPrieto-Merino, Daviden_US
dc.contributor.authorDehghan, Abbasen_US
dc.contributor.authorTrompet, Stellaen_US
dc.contributor.authorWong, Andrewen_US
dc.contributor.authorCavadino, Alanaen_US
dc.contributor.authorDrogan, Dagmaren_US
dc.contributor.authorPadmanabhan, Sandoshen_US
dc.contributor.authorLi, Shanshanen_US
dc.contributor.authorYesupriya, Ajayen_US
dc.contributor.authorLeusink, Maartenen_US
dc.contributor.authorSundstrom, Johanen_US
dc.contributor.authorHubacek, Jaroslav Aen_US
dc.contributor.authorPikhart, Hyneken_US
dc.contributor.authorSwerdlow, Daniel Ien_US
dc.contributor.authorPanayiotou, Andrie Gen_US
dc.contributor.authorBorinskaya, Svetlana Aen_US
dc.contributor.authorFinan, Chrisen_US
dc.contributor.authorShah, Soniaen_US
dc.contributor.authorKuchenbaecker, Karoline Ben_US
dc.contributor.authorShah, Tinaen_US
dc.contributor.authorEngmann, Jorgenen_US
dc.contributor.authorFolkersen, Lasseen_US
dc.contributor.authorEriksson, Peren_US
dc.contributor.authorRicceri, Fulvioen_US
dc.contributor.authorMelander, Olleen_US
dc.contributor.authorSacerdote, Carlottaen_US
dc.contributor.authorGamble, Dale Men_US
dc.contributor.authorRayaprolu, Srutien_US
dc.contributor.authorRoss, Owen Aen_US
dc.contributor.authorMcLachlan, Stelaen_US
dc.contributor.authorVikhireva, Olgaen_US
dc.contributor.authorSluijs, Ivonneen_US
dc.contributor.authorScott, Robert Aen_US
dc.contributor.authorAdamkova, Veraen_US
dc.contributor.authorFlicker, Leonen_US
dc.contributor.authorvan Bockxmeer, Frank Men_US
dc.contributor.authorPower, Christineen_US
dc.contributor.authorMarques-Vidal, Pedroen_US
dc.contributor.authorMeade, Tomen_US
dc.contributor.authorMarmot, Michael Gen_US
dc.contributor.authorFerro, Jose Men_US
dc.contributor.authorPaulos-Pinheiro, Sofiaen_US
dc.contributor.authorHumphries, Steve Een_US
dc.contributor.authorTalmud, Philippa Jen_US
dc.contributor.authorLeach, Irene Mateoen_US
dc.contributor.authorVerweij, Nieken_US
dc.contributor.authorLinneberg, Allanen_US
dc.contributor.authorSkaaby, Teaen_US
dc.contributor.authorDoevendans, Pieter Aen_US
dc.contributor.authorCramer, Maarten Jen_US
dc.contributor.authorvan der Harst, Pimen_US
dc.contributor.authorKlungel, Olaf Hen_US
dc.contributor.authorDowling, Nicole Fen_US
dc.contributor.authorDominiczak, Anna Fen_US
dc.contributor.authorKumari, Meenaen_US
dc.contributor.authorNicolaides, Andrew Nen_US
dc.contributor.authorWeikert, Corneliaen_US
dc.contributor.authorBoeing, Heineren_US
dc.contributor.authorEbrahim, Shahen_US
dc.contributor.authorGaunt, Tom Ren_US
dc.contributor.authorPrice, Jackie Fen_US
dc.contributor.authorLannfelt, Larsen_US
dc.contributor.authorPeasey, Anneen_US
dc.contributor.authorKubinova, Ruzenaen_US
dc.contributor.authorPajak, Andrzejen_US
dc.contributor.authorMalyutina, Sofiaen_US
dc.contributor.authorVoevoda, Mikhail Ien_US
dc.contributor.authorTamosiunas, Abdonasen_US
dc.contributor.authorMaitland-van der Zee, Anke Hen_US
dc.contributor.authorNorman, Paul Een_US
dc.contributor.authorHankey, Graeme Jen_US
dc.contributor.authorBergmann, Manuela Men_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorFranco, Oscar Hen_US
dc.contributor.authorCooper, Jackieen_US
dc.contributor.authorPalmen, Juttaen_US
dc.contributor.authorSpiering, Wilkoen_US
dc.contributor.authorde Jong, Pim Aen_US
dc.contributor.authorKuh, Dianaen_US
dc.contributor.authorHardy, Rebeccaen_US
dc.contributor.authorUitterlinden, Andre Gen_US
dc.contributor.authorIkram, M Arfanen_US
dc.contributor.authorFord, Ianen_US
dc.contributor.authorHyppönen, Elinaen_US
dc.contributor.authorAlmeida, Osvaldo Pen_US
dc.contributor.authorWareham, Nicholas Jen_US
dc.contributor.authorKhaw, Kay-Teeen_US
dc.contributor.authorHamsten, Andersen_US
dc.contributor.authorHusemoen, Lise Lotte Nen_US
dc.contributor.authorTjønneland, Anneen_US
dc.contributor.authorTolstrup, Janne Sen_US
dc.contributor.authorRimm, Ericen_US
dc.contributor.authorBeulens, Joline W Jen_US
dc.contributor.authorVerschuren, W M Moniqueen_US
dc.contributor.authorOnland-Moret, N Charlotteen_US
dc.contributor.authorHofker, Marten Hen_US
dc.contributor.authorWannamethee, S Goyaen_US
dc.contributor.authorWhincup, Peter Hen_US
dc.contributor.authorMorris, Richarden_US
dc.contributor.authorVicente, Astrid Men_US
dc.contributor.authorWatkins, Hughen_US
dc.contributor.authorFarrall, Martinen_US
dc.contributor.authorJukema, J Wouteren_US
dc.contributor.authorMeschia, Jamesen_US
dc.contributor.authorCupples, L Adrienneen_US
dc.contributor.authorSharp, Stephen Jen_US
dc.contributor.authorFornage, Myriamen_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorLaCroix, Andrea Zen_US
dc.contributor.authorDai, James Yen_US
dc.contributor.authorLanktree, Matthew Ben_US
dc.contributor.authorSiscovick, David Sen_US
dc.contributor.authorJorgenson, Ericen_US
dc.contributor.authorSpring, Bonnieen_US
dc.contributor.authorCoresh, Josefen_US
dc.contributor.authorLi, Yun Ren_US
dc.contributor.authorBuxbaum, Sarah Gen_US
dc.contributor.authorSchreiner, Pamela Jen_US
dc.contributor.authorEllison, R Curtisen_US
dc.contributor.authorTsai, Michael Yen_US
dc.contributor.authorPatel, Sanjay Ren_US
dc.contributor.authorRedline, Susanen_US
dc.contributor.authorJohnson, Andrew Den_US
dc.contributor.authorHoogeveen, Ron Cen_US
dc.contributor.authorHakonarson, Hakonen_US
dc.contributor.authorRotter, Jerome Ien_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorde Bakker, Paul I Wen_US
dc.contributor.authorKivimaki, Mikaen_US
dc.contributor.authorAsselbergs, Folkert Wen_US
dc.contributor.authorSattar, Naveeden_US
dc.contributor.authorLawlor, Debbie Aen_US
dc.contributor.authorWhittaker, Johnen_US
dc.contributor.authorDavey Smith, Georgeen_US
dc.contributor.authorMukamal, Kennethen_US
dc.contributor.authorPsaty, Bruce Men_US
dc.contributor.authorWilson, James Gen_US
dc.contributor.authorLange, Leslie Aen_US
dc.contributor.authorHamidovic, Ajnaen_US
dc.contributor.authorHingorani, Aroon Den_US
dc.contributor.authorNordestgaard, Børge Gen_US
dc.contributor.authorBobak, Martinen_US
dc.contributor.authorLeon, David Aen_US
dc.contributor.authorLangenberg, Claudiaen_US
dc.contributor.authorPalmer, Tom Men_US
dc.contributor.authorReiner, Alex Pen_US
dc.contributor.authorKeating, Brendan Jen_US
dc.contributor.authorDudbridge, Franken_US
dc.contributor.authorCasas, Juan Pen_US
dc.date.accessioned2014-08-13T13:58:19Z
dc.date.issued2014en_US
dc.identifier.citationHolmes, M. V., C. E. Dale, L. Zuccolo, R. J. Silverwood, Y. Guo, Z. Ye, D. Prieto-Merino, et al. 2014. “Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.” BMJ : British Medical Journal 349 (1): g4164. doi:10.1136/bmj.g4164. http://dx.doi.org/10.1136/bmj.g4164.en
dc.identifier.issn0959-8138en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717390
dc.description.abstractObjective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (−0.88 (−1.19 to −0.56) mm Hg), interleukin-6 levels (−5.2% (−7.8 to −2.4%)), waist circumference (−0.3 (−0.6 to −0.1) cm), and body mass index (−0.17 (−0.24 to −0.10) kg/m2). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.en
dc.language.isoen_USen
dc.publisherBMJ Publishing Group Ltd.en
dc.relation.isversionofdoi:10.1136/bmj.g4164en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091648/pdf/en
dash.licenseLAAen_US
dc.titleAssociation between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant dataen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMJ : British Medical Journalen
dash.depositing.authorRimm, Ericen_US
dc.date.available2014-08-13T13:58:19Z
dc.identifier.doi10.1136/bmj.g4164*
dash.authorsorderedfalse
dash.contributor.affiliatedRimm, Eric
dash.contributor.affiliatedRedline, Susan
dash.contributor.affiliatedMukamal, Ken
dash.contributor.affiliatedPatel, Sanjay R.


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