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dc.contributor.authorAgam, Yigalen_US
dc.contributor.authorVangel, Marken_US
dc.contributor.authorRoffman, Joshua L.en_US
dc.contributor.authorGallagher, Patience J.en_US
dc.contributor.authorChaponis, Jonathanen_US
dc.contributor.authorHaddad, Stephenen_US
dc.contributor.authorGoff, Donald C.en_US
dc.contributor.authorGreenberg, Jennifer L.en_US
dc.contributor.authorWilhelm, Sabineen_US
dc.contributor.authorSmoller, Jordan W.en_US
dc.contributor.authorManoach, Dara S.en_US
dc.date.accessioned2014-08-13T13:58:21Z
dc.date.issued2014en_US
dc.identifier.citationAgam, Y., M. Vangel, J. L. Roffman, P. J. Gallagher, J. Chaponis, S. Haddad, D. C. Goff, et al. 2014. “Dissociable Genetic Contributions to Error Processing: A Multimodal Neuroimaging Study.” PLoS ONE 9 (7): e101784. doi:10.1371/journal.pone.0101784. http://dx.doi.org/10.1371/journal.pone.0101784.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717392
dc.description.abstractBackground: Neuroimaging studies reliably identify two markers of error commission: the error-related negativity (ERN), an event-related potential, and functional MRI activation of the dorsal anterior cingulate cortex (dACC). While theorized to reflect the same neural process, recent evidence suggests that the ERN arises from the posterior cingulate cortex not the dACC. Here, we tested the hypothesis that these two error markers also have different genetic mediation. Methods: We measured both error markers in a sample of 92 comprised of healthy individuals and those with diagnoses of schizophrenia, obsessive-compulsive disorder or autism spectrum disorder. Participants performed the same task during functional MRI and simultaneously acquired magnetoencephalography and electroencephalography. We examined the mediation of the error markers by two single nucleotide polymorphisms: dopamine D4 receptor (DRD4) C-521T (rs1800955), which has been associated with the ERN and methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133), which has been associated with error-related dACC activation. We then compared the effects of each polymorphism on the two error markers modeled as a bivariate response. Results: We replicated our previous report of a posterior cingulate source of the ERN in healthy participants in the schizophrenia and obsessive-compulsive disorder groups. The effect of genotype on error markers did not differ significantly by diagnostic group. DRD4 C-521T allele load had a significant linear effect on ERN amplitude, but not on dACC activation, and this difference was significant. MTHFR C677T allele load had a significant linear effect on dACC activation but not ERN amplitude, but the difference in effects on the two error markers was not significant. Conclusions: DRD4 C-521T, but not MTHFR C677T, had a significant differential effect on two canonical error markers. Together with the anatomical dissociation between the ERN and error-related dACC activation, these findings suggest that these error markers have different neural and genetic mediation.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0101784en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092014/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectNeuroscienceen
dc.subjectCognitive Scienceen
dc.subjectCognitive Psychologyen
dc.subjectLearningen
dc.subjectHuman Learningen
dc.subjectNeuroimagingen
dc.subjectFunctional Magnetic Resonance Imagingen
dc.subjectNeurophysiologyen
dc.subjectBrain Electrophysiologyen
dc.subjectElectroencephalographyen
dc.subjectLearning and Memoryen
dc.titleDissociable Genetic Contributions to Error Processing: A Multimodal Neuroimaging Studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorVangel, Marken_US
dc.date.available2014-08-13T13:58:21Z
dc.identifier.doi10.1371/journal.pone.0101784*
dash.authorsorderedfalse
dash.contributor.affiliatedGreenberg, Jennifer
dash.contributor.affiliatedWilhelm, Sabine
dash.contributor.affiliatedManoach, Dara
dash.contributor.affiliatedRoffman, Joshua
dash.contributor.affiliatedVangel, Mark
dash.contributor.affiliatedSmoller, Jordan


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