Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study

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Author
Ferrari, Pietro
Licaj, Idlir
Muller, David C
Kragh Andersen, Per
Johansson, Mattias
Boeing, Heiner
Weiderpass, Elisabete
Dossus, Laure
Dartois, Laureen
Fagherazzi, Guy
Bradbury, Kathryn E
Khaw, Kay-Tee
Wareham, Nick
Duell, Eric J
Barricarte, Aurelio
Molina-Montes, Esther
Sanchez, Carmen Navarro
Arriola, Larraitz
Wallström, Peter
Tjønneland, Anne
Olsen, Anja
Trichopoulou, Antonia
Benetou, Vasiliki
Tumino, Rosario
Agnoli, Claudia
Sacerdote, Carlotta
Palli, Domenico
Li, Kuanrong
Kaaks, Rudolf
Peeters, Petra
Beulens, Joline WJ
Nunes, Luciana
Gunter, Marc
Norat, Teresa
Overvad, Kim
Brennan, Paul
Riboli, Elio
Romieu, Isabelle
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1136/bmjopen-2014-005245Metadata
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Ferrari, P., I. Licaj, D. C. Muller, P. Kragh Andersen, M. Johansson, H. Boeing, E. Weiderpass, et al. 2014. “Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study.” BMJ Open 4 (7): e005245. doi:10.1136/bmjopen-2014-005245. http://dx.doi.org/10.1136/bmjopen-2014-005245.Abstract
Objectives: To investigate the role of factors that modulate the association between alcohol and mortality, and to provide estimates of absolute risk of death. Design: The European Prospective Investigation into Cancer and nutrition (EPIC). Setting: 23 centres in 10 countries. Participants: 380 395 men and women, free of cancer, diabetes, heart attack or stroke at enrolment, followed up for 12.6 years on average. Main outcome measures 20 453 fatal events, of which 2053 alcohol-related cancers (ARC, including cancers of upper aerodigestive tract, liver, colorectal and female breast), 4187 cardiovascular diseases/coronary heart disease (CVD/CHD), 856 violent deaths and injuries. Lifetime alcohol use was assessed at recruitment. Results: HRs comparing extreme drinkers (≥30 g/day in women and ≥60 g/day in men) to moderate drinkers (0.1–4.9 g/day) were 1.27 (95% CI 1.13 to 1.43) in women and 1.53 (1.39 to 1.68) in men. Strong associations were observed for ARC mortality, in men particularly, and for violent deaths and injuries, in men only. No associations were observed for CVD/CHD mortality among drinkers, whereby HRs were higher in never compared to moderate drinkers. Overall mortality seemed to be more strongly related to beer than wine use, particularly in men. The 10-year risks of overall death for women aged 60 years, drinking more than 30 g/day was 5% and 7%, for never and current smokers, respectively. Corresponding figures in men consuming more than 60 g/day were 11% and 18%, in never and current smokers, respectively. In competing risks analyses, mortality due to CVD/CHD was more pronounced than ARC in men, while CVD/CHD and ARC mortality were of similar magnitude in women. Conclusions: In this large European cohort, alcohol use was positively associated with overall mortality, ARC and violent death and injuries, but marginally to CVD/CHD. Absolute risks of death observed in EPIC suggest that alcohol is an important determinant of total mortality.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091394/pdf/Terms of Use
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