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dc.contributor.authorMa, Baoshanen_US
dc.contributor.authorHuang, Jinyanen_US
dc.contributor.authorLiang, Limingen_US
dc.date.accessioned2014-08-13T13:58:42Z
dc.date.issued2014en_US
dc.identifier.citationMa, Baoshan, Jinyan Huang, and Liming Liang. 2014. “RTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analyses.” Database: The Journal of Biological Databases and Curation 2014 (1): bau066. doi:10.1093/database/bau066. http://dx.doi.org/10.1093/database/bau066.en
dc.identifier.issn1758-0463en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717430
dc.description.abstractOur database tool, called Real-Time Engine for Expression Quantitative Trait Loci Analyses (RTeQTL), can efficiently provide eQTL association results that are not available in existing eQTL databases browsers. These functions include (i) single SNP (single-nucleotide polymorphism) and (ii) two-SNP conditional eQTL effects on gene expression regardless of the magnitude of P-values. The database is based on lymphoblastoid cell lines from >900 samples with global gene expression and genome-wide genotyped and imputed SNP data. The detailed result for any pairs of gene and SNPs can be efficiently computed and browsed online, as well as downloaded in batch mode. This is the only tool that can assess the independent effect of a disease- or trait-associated SNP on gene expression conditioning on other SNPs of interest, such as the top eQTL of the same gene. It is also useful to identify eQTLs for candidate genes, which are often missed in existing eQTL browsers, which only store results with genome-wide significant P-value. Additional analyses stratifying by gender can also be easily achieved by this tool. Database URL: http://eqtl.rc.fas.harvard.edu/en
dc.language.isoen_USen
dc.publisherOxford University Pressen
dc.relation.isversionofdoi:10.1093/database/bau066en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103423/pdf/en
dash.licenseLAAen_US
dc.titleRTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analysesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDatabase: The Journal of Biological Databases and Curationen
dash.depositing.authorLiang, Limingen_US
dc.date.available2014-08-13T13:58:42Z
dc.identifier.doi10.1093/database/bau066*
dash.contributor.affiliatedLiang, Liming


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