African origin of the malaria parasite Plasmodium vivax
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Author
Liu, Weimin
Li, Yingying
Shaw, Katharina S.
Learn, Gerald H.
Plenderleith, Lindsey J.
Malenke, Jordan A.
Sundararaman, Sesh A.
Ramirez, Miguel A.
Crystal, Patricia A.
Smith, Andrew G.
Bibollet-Ruche, Frederic
Ayouba, Ahidjo
Locatelli, Sabrina
Esteban, Amandine
Mouacha, Fatima
Guichet, Emilande
Butel, Christelle
Ahuka-Mundeke, Steve
Inogwabini, Bila-Isia
Ndjango, Jean-Bosco N.
Speede, Sheri
Sanz, Crickette M.
Morgan, David B.
Gonder, Mary K.
Kranzusch, Philip J.
Walsh, Peter D.
Georgiev, Alexander V.
Muller, Martin N.
Piel, Alex K.
Stewart, Fiona A.
Wilson, Michael L.
Pusey, Anne E.
Cui, Liwang
Wang, Zenglei
Färnert, Anna
Sutherland, Colin J.
Nolder, Debbie
Hart, John A.
Hart, Terese B.
Bertolani, Paco
Gillis, Amethyst
LeBreton, Matthew
Tafon, Babila
Kiyang, John
Djoko, Cyrille F.
Schneider, Bradley S.
Wolfe, Nathan D.
Mpoudi-Ngole, Eitel
Delaporte, Eric
Carter, Richard
Culleton, Richard L.
Shaw, George M.
Rayner, Julian C.
Peeters, Martine
Hahn, Beatrice H.
Sharp, Paul M.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/ncomms4346Metadata
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Liu, W., Y. Li, K. S. Shaw, G. H. Learn, L. J. Plenderleith, J. A. Malenke, S. A. Sundararaman, et al. 2014. “African origin of the malaria parasite Plasmodium vivax.” Nature communications 5 (1): 3346. doi:10.1038/ncomms4346. http://dx.doi.org/10.1038/ncomms4346.Abstract
Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089193/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717448
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