Integrating protein-protein interaction networks with phenotypes reveals signs of interactions

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Integrating protein-protein interaction networks with phenotypes reveals signs of interactions

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Title: Integrating protein-protein interaction networks with phenotypes reveals signs of interactions
Author: Vinayagam, Arunachalam; Zirin, Jonathan; Roesel, Charles; Hu, Yanhui; Yilmazel, Bahar; Samsonova, Anastasia A.; Neumüller, Ralph A.; Mohr, Stephanie E.; Perrimon, Norbert

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Citation: Vinayagam, Arunachalam, Jonathan Zirin, Charles Roesel, Yanhui Hu, Bahar Yilmazel, Anastasia A. Samsonova, Ralph A. Neumüller, Stephanie E. Mohr, and Norbert Perrimon. 2013. “Integrating protein-protein interaction networks with phenotypes reveals signs of interactions.” Nature methods 11 (1): 10.1038/nmeth.2733. doi:10.1038/nmeth.2733. http://dx.doi.org/10.1038/nmeth.2733.
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Abstract: A major objective of systems biology is to organize molecular interactions as networks and to characterize information-flow within networks. We describe a computational framework to integrate protein-protein interaction (PPI) networks and genetic screens to predict the “signs” of interactions (i.e. activation/inhibition relationships). We constructed a Drosophila melanogaster signed PPI network, consisting of 6,125 signed PPIs connecting 3,352 proteins that can be used to identify positive and negative regulators of signaling pathways and protein complexes. We identified an unexpected role for the metabolic enzymes Enolase and Aldo-keto reductase as positive and negative regulators of proteolysis, respectively. Characterization of the activation/inhibition relationships between physically interacting proteins within signaling pathways will impact our understanding of many biological functions, including signal transduction and mechanisms of disease.
Published Version: doi:10.1038/nmeth.2733
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877743/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717461
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