Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study

DSpace/Manakin Repository

Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study

Citable link to this page

 

 
Title: Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study
Author: Whitford, Thomas J.; Lee, Sun Woo; Oh, Jungsu S.; de Luis-Garcia, Rodrigo; Savadjiev, Peter; Alvarado, Jorge L.; Westin, Carl-Fredrik; Niznikiewicz, Margaret; Nestor, Paul G.; McCarley, Robert W.; Kubicki, Marek; Shenton, Martha E. ORCID  0000-0003-4235-7879

Note: Order does not necessarily reflect citation order of authors.

Citation: Whitford, T. J., S. W. Lee, J. S. Oh, R. de Luis-Garcia, P. Savadjiev, J. L. Alvarado, C. Westin, et al. 2014. “Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study.” NeuroImage : Clinical 5 (1): 93-99. doi:10.1016/j.nicl.2014.06.003. http://dx.doi.org/10.1016/j.nicl.2014.06.003.
Full Text & Related Files:
Abstract: The cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a conglomeration of discrete sub-connections. The present study aimed to use Diffusion Tensor tractography to subdivide the CB into its constituent sub-connections, and to investigate the structural integrity of these sub-connections in patients with schizophrenia and matched healthy controls. Diffusion Tensor Imaging scans were acquired from 24 patients diagnosed with chronic schizophrenia and 26 matched healthy controls. Deterministic tractography was used in conjunction with FreeSurfer-based regions-of-interest to subdivide the CB into 5 sub-connections (I1 to I5). The patients with schizophrenia exhibited subnormal levels of FA in two cingulum sub-connections, specifically the fibers connecting the rostral and caudal anterior cingulate gyrus (I1) and the fibers connecting the isthmus of the cingulate with the parahippocampal cortex (I4). Furthermore, while FA in the I1 sub-connection was correlated with the severity of patients' positive symptoms (specifically hallucinations and delusions), FA in the I4 sub-connection was correlated with the severity of patients' negative symptoms (specifically affective flattening and anhedonia/asociality). These results support the notion that the CB is a conglomeration of structurally interconnected yet functionally distinct sub-connections, of which only a subset are abnormal in patients with schizophrenia. Furthermore, while acknowledging the fact that the present study only investigated the CB, these results suggest that the positive and negative symptoms of schizophrenia may have distinct neurobiological underpinnings.
Published Version: doi:10.1016/j.nicl.2014.06.003
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081981/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717472
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters