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dc.contributor.authorWhitford, Thomas J.en_US
dc.contributor.authorLee, Sun Wooen_US
dc.contributor.authorOh, Jungsu S.en_US
dc.contributor.authorde Luis-Garcia, Rodrigoen_US
dc.contributor.authorSavadjiev, Peteren_US
dc.contributor.authorAlvarado, Jorge L.en_US
dc.contributor.authorWestin, Carl-Fredriken_US
dc.contributor.authorNiznikiewicz, Margareten_US
dc.contributor.authorNestor, Paul G.en_US
dc.contributor.authorMcCarley, Robert W.en_US
dc.contributor.authorKubicki, Mareken_US
dc.contributor.authorShenton, Martha E.en_US
dc.date.accessioned2014-08-13T13:59:21Z
dc.date.issued2014en_US
dc.identifier.citationWhitford, T. J., S. W. Lee, J. S. Oh, R. de Luis-Garcia, P. Savadjiev, J. L. Alvarado, C. Westin, et al. 2014. “Localized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography study.” NeuroImage : Clinical 5 (1): 93-99. doi:10.1016/j.nicl.2014.06.003. http://dx.doi.org/10.1016/j.nicl.2014.06.003.en
dc.identifier.issn2213-1582en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717472
dc.description.abstractThe cingulum bundle (CB) connects gray matter structures of the limbic system and as such has been implicated in the etiology of schizophrenia. There is growing evidence to suggest that the CB is actually comprised of a conglomeration of discrete sub-connections. The present study aimed to use Diffusion Tensor tractography to subdivide the CB into its constituent sub-connections, and to investigate the structural integrity of these sub-connections in patients with schizophrenia and matched healthy controls. Diffusion Tensor Imaging scans were acquired from 24 patients diagnosed with chronic schizophrenia and 26 matched healthy controls. Deterministic tractography was used in conjunction with FreeSurfer-based regions-of-interest to subdivide the CB into 5 sub-connections (I1 to I5). The patients with schizophrenia exhibited subnormal levels of FA in two cingulum sub-connections, specifically the fibers connecting the rostral and caudal anterior cingulate gyrus (I1) and the fibers connecting the isthmus of the cingulate with the parahippocampal cortex (I4). Furthermore, while FA in the I1 sub-connection was correlated with the severity of patients' positive symptoms (specifically hallucinations and delusions), FA in the I4 sub-connection was correlated with the severity of patients' negative symptoms (specifically affective flattening and anhedonia/asociality). These results support the notion that the CB is a conglomeration of structurally interconnected yet functionally distinct sub-connections, of which only a subset are abnormal in patients with schizophrenia. Furthermore, while acknowledging the fact that the present study only investigated the CB, these results suggest that the positive and negative symptoms of schizophrenia may have distinct neurobiological underpinnings.en
dc.language.isoen_USen
dc.publisherElsevieren
dc.relation.isversionofdoi:10.1016/j.nicl.2014.06.003en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081981/pdf/en
dash.licenseLAAen_US
dc.subjectSchizophreniaen
dc.subjectCingulum bundleen
dc.subjectCingulate gyrusen
dc.subjectDiffusion Tensor Imagingen
dc.subjectDTIen
dc.subjectFractional Anisotropyen
dc.titleLocalized abnormalities in the cingulum bundle in patients with schizophrenia: A Diffusion Tensor tractography studyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNeuroImage : Clinicalen
dash.depositing.authorWhitford, Thomas J.en_US
dc.date.available2014-08-13T13:59:21Z
dc.identifier.doi10.1016/j.nicl.2014.06.003*
dash.authorsorderedfalse
dash.identifier.orcid0000-0003-4235-7879*
dash.contributor.affiliatedSavadjiev, Peter
dash.contributor.affiliatedWestin, Carl-Fredrik
dash.contributor.affiliatedNiznikiewicz, Margaret
dash.contributor.affiliatedNestor, Paul
dash.contributor.affiliatedMcCarley, Robert William
dash.contributor.affiliatedWhitford, T
dash.contributor.affiliatedKubicki, Marek
dash.contributor.affiliatedShenton, Martha
dc.identifier.orcid0000-0003-4235-7879


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