Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

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Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

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Title: Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
Author: Nakayama, Atsushi; Okano, Akinori; Feng, Yiqing; Collins, James C.; Collins, Karen C.; Walsh, Christopher T.; Boger, Dale L.

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Citation: Nakayama, Atsushi, Akinori Okano, Yiqing Feng, James C. Collins, Karen C. Collins, Christopher T. Walsh, and Dale L. Boger. 2014. “Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate.” Organic Letters 16 (13): 3572-3575. doi:10.1021/ol501568t. http://dx.doi.org/10.1021/ol501568t.
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Abstract: Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.
Published Version: doi:10.1021/ol501568t
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084835/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717480
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