Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women

View/ Open
Author
Kim, Hye Won
Kim, Yang-Hyun
Han, Kyungdo
Nam, Ga Eun
Kim, Gwang Seon
Han, Byoung-Duck
Lee, Anna
Ahn, Ji Yong
Ko, Byung Joon
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1371/journal.pone.0101852Metadata
Show full item recordCitation
Kim, Hye Won, Yang-Hyun Kim, Kyungdo Han, Ga Eun Nam, Gwang Seon Kim, Byoung-Duck Han, Anna Lee, Ji Yong Ahn, and Byung Joon Ko. 2014. “Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women.” PLoS ONE 9 (7): e101852. doi:10.1371/journal.pone.0101852. http://dx.doi.org/10.1371/journal.pone.0101852.Abstract
Purpose Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of atrophic gastritis as a related factor for osteoporosis is unclear. We investigated the relationship between atrophic gastritis and osteoporosis in postmenopausal women over 60 years of age. Subjects and Methods A total of 401 postmenopausal women were included in this cross-sectional study, which was conducted during their medical check-ups. Bone mineral densitometry was measured using a dual energy X-ray absorptiometry. Atrophic gastritis was defined endoscopically if gastric mucosa in the antrum and the body were found to be atrophied and thinned and submucosal vessels could be well visualized. Results: The proportion of people with atrophic gastritis was higher in the osteoporotic group than in the group without osteoporosis. A linear relationship was observed in the proportion of atrophic gastritis according to the categories of normal, osteopenia, and osteoporosis at the lumbar spine (p for trend = 0.039) and femur (p for trend = 0.001). A multiple logistic regression analysis revealed that the presence of atrophic gastritis was associated with an increased odds of osteoporosis after adjusting for age, body mass index, triglyceride, high-density lipoprotein cholesterol, alcohol consumption, and smoking status (odds ratio 1.89, 95% confidence interval 1.15–3.11). Conclusions: Atrophic gastritis is associated with an increased likelihood of osteoporosis in Korean elderly women.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087012/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717489
Collections
- HMS Scholarly Articles [17714]
Contact administrator regarding this item (to report mistakes or request changes)