Aberrant error processing in relation to symptom severity in obsessive–compulsive disorder: A multimodal neuroimaging study

DSpace/Manakin Repository

Aberrant error processing in relation to symptom severity in obsessive–compulsive disorder: A multimodal neuroimaging study

Citable link to this page

 

 
Title: Aberrant error processing in relation to symptom severity in obsessive–compulsive disorder: A multimodal neuroimaging study
Author: Agam, Yigal; Greenberg, Jennifer L.; Isom, Marlisa; Falkenstein, Martha J.; Jenike, Eric; Wilhelm, Sabine; Manoach, Dara S.

Note: Order does not necessarily reflect citation order of authors.

Citation: Agam, Yigal, Jennifer L. Greenberg, Marlisa Isom, Martha J. Falkenstein, Eric Jenike, Sabine Wilhelm, and Dara S. Manoach. 2014. “Aberrant error processing in relation to symptom severity in obsessive–compulsive disorder: A multimodal neuroimaging study.” NeuroImage : Clinical 5 (1): 141-151. doi:10.1016/j.nicl.2014.06.002. http://dx.doi.org/10.1016/j.nicl.2014.06.002.
Full Text & Related Files:
Abstract: Background: Obsessive–compulsive disorder (OCD) is characterized by maladaptive repetitive behaviors that persist despite feedback. Using multimodal neuroimaging, we tested the hypothesis that this behavioral rigidity reflects impaired use of behavioral outcomes (here, errors) to adaptively adjust responses. We measured both neural responses to errors and adjustments in the subsequent trial to determine whether abnormalities correlate with symptom severity. Since error processing depends on communication between the anterior and the posterior cingulate cortex, we also examined the integrity of the cingulum bundle with diffusion tensor imaging. Methods: Participants performed the same antisaccade task during functional MRI and electroencephalography sessions. We measured error-related activation of the anterior cingulate cortex (ACC) and the error-related negativity (ERN). We also examined post-error adjustments, indexed by changes in activation of the default network in trials surrounding errors. Results: OCD patients showed intact error-related ACC activation and ERN, but abnormal adjustments in the post- vs. pre-error trial. Relative to controls, who responded to errors by deactivating the default network, OCD patients showed increased default network activation including in the rostral ACC (rACC). Greater rACC activation in the post-error trial correlated with more severe compulsions. Patients also showed increased fractional anisotropy (FA) in the white matter underlying rACC. Conclusions: Impaired use of behavioral outcomes to adaptively adjust neural responses may contribute to symptoms in OCD. The rACC locus of abnormal adjustment and relations with symptoms suggests difficulty suppressing emotional responses to aversive, unexpected events (e.g., errors). Increased structural connectivity of this paralimbic default network region may contribute to this impairment.
Published Version: doi:10.1016/j.nicl.2014.06.002
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096999/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717514
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters