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dc.contributor.authorMa, Linaen_US
dc.contributor.authorCui, Pengen_US
dc.contributor.authorZhu, Jiangen_US
dc.contributor.authorZhang, Zhihuaen_US
dc.contributor.authorZhang, Zhangen_US
dc.date.accessioned2014-08-13T13:59:48Z
dc.date.issued2014en_US
dc.identifier.citationMa, Lina, Peng Cui, Jiang Zhu, Zhihua Zhang, and Zhang Zhang. 2014. “Translational selection in human: more pronounced in housekeeping genes.” Biology Direct 9 (1): 17. doi:10.1186/1745-6150-9-17. http://dx.doi.org/10.1186/1745-6150-9-17.en
dc.identifier.issn1745-6150en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717526
dc.description.abstractBackground: Translational selection is a ubiquitous and significant mechanism to regulate protein expression in prokaryotes and unicellular eukaryotes. Recent evidence has shown that translational selection is weakly operative in highly expressed genes in human and other vertebrates. However, it remains unclear whether translational selection acts differentially on human genes depending on their expression patterns. Results: Here we report that human housekeeping (HK) genes that are strictly defined as genes that are expressed ubiquitously and consistently in most or all tissues, are under stronger translational selection. Conclusions: These observations clearly show that translational selection is also closely associated with expression pattern. Our results suggest that human HK genes are more efficiently and/or accurately translated into proteins, which will inevitably open up a new understanding of HK genes and the regulation of gene expression. Reviewers This article was reviewed by Yuan Yuan, Baylor College of Medicine; Han Liang, University of Texas MD Anderson Cancer Center (nominated by Dr Laura Landweber) Eugene Koonin, NCBI, NLM, NIH, United States of America Sandor Pongor, International Centre for Genetic Engineering and biotechnology (ICGEB), Italy.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1745-6150-9-17en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100034/pdf/en
dash.licenseLAAen_US
dc.subjectTranslational selectionen
dc.subjectCodon usage biasen
dc.subjectExpression regulationen
dc.subjectHousekeeping geneen
dc.subjectTissue-specific geneen
dc.titleTranslational selection in human: more pronounced in housekeeping genesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBiology Directen
dash.depositing.authorZhu, Jiangen_US
dc.date.available2014-08-13T13:59:48Z
dc.identifier.doi10.1186/1745-6150-9-17*
dash.authorsorderedfalse
dash.contributor.affiliatedZhu, Jiang


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