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dc.contributor.authorCavallari, Micheleen_US
dc.contributor.authorCeccarelli, Antoniaen_US
dc.contributor.authorWang, Guang-Yien_US
dc.contributor.authorMoscufo, Nicolaen_US
dc.contributor.authorHannoun, Salemen_US
dc.contributor.authorMatulis, Christina R.en_US
dc.contributor.authorJackson, Jonathan S.en_US
dc.contributor.authorGlanz, Bonnie I.en_US
dc.contributor.authorBakshi, Rohiten_US
dc.contributor.authorNeema, Mohiten_US
dc.contributor.authorGuttmann, Charles R. G.en_US
dc.date.accessioned2014-08-13T13:59:57Z
dc.date.issued2014en_US
dc.identifier.citationCavallari, M., A. Ceccarelli, G. Wang, N. Moscufo, S. Hannoun, C. R. Matulis, J. S. Jackson, et al. 2014. “Microstructural Changes in the Striatum and Their Impact on Motor and Neuropsychological Performance in Patients with Multiple Sclerosis.” PLoS ONE 9 (7): e101199. doi:10.1371/journal.pone.0101199. http://dx.doi.org/10.1371/journal.pone.0101199.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717546
dc.description.abstractGrey matter (GM) damage is a clinically relevant feature of multiple sclerosis (MS) that has been previously assessed with diffusion tensor imaging (DTI). Fractional anisotropy (FA) of the basal ganglia and thalamus might be increased in MS patients, and correlates with disability scores. Despite the established role of the striatum and thalamus in motor control, mood and cognition, the impact of DTI changes within these structures on motor and neuropsychological performance has not yet been specifically addressed in MS. We investigated DTI metrics of deep GM nuclei and their potential association with mobility and neuropsychological function. DTI metrics from 3T MRI were assessed in the caudate, putamen, and thalamus of 30 MS patients and 10 controls. Sixteen of the patients underwent neuropsychological testing. FA of the caudate and putamen was higher in MS patients compared to controls. Caudate FA correlated with Expanded Disability Status Scale score, Ambulation Index, and severity of depressive symptomatology. Putamen and thalamus FA correlated with deficits in memory tests. In contrast, cerebral white matter (WM) lesion burden showed no significant correlation with any of the disability, mobility and psychometric parameters. Our findings support evidence of FA changes in the basal ganglia in MS patients, as well as deep GM involvement in disabling features of MS, including mobility and cognitive impairment. Deep GM FA appears to be a more sensitive correlate of disability than WM lesion burden.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0101199en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105540/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectAnatomyen
dc.subjectNervous Systemen
dc.subjectMotor Systemen
dc.subjectImmunologyen
dc.subjectClinical Immunologyen
dc.subjectAutoimmune Diseasesen
dc.subjectMultiple Sclerosisen
dc.subjectNeuroscienceen
dc.subjectNeuroimagingen
dc.subjectNeuropsychologyen
dc.subjectPsychologyen
dc.subjectMedicine and Health Sciencesen
dc.subjectDiagnostic Medicineen
dc.subjectDiagnostic Radiologyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMental Health and Psychiatryen
dc.subjectNeurologyen
dc.subjectDemyelinating Disordersen
dc.subjectRadiology and Imagingen
dc.titleMicrostructural Changes in the Striatum and Their Impact on Motor and Neuropsychological Performance in Patients with Multiple Sclerosisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorCavallari, Micheleen_US
dc.date.available2014-08-13T13:59:57Z
dc.identifier.doi10.1371/journal.pone.0101199*
dash.authorsorderedfalse
dash.contributor.affiliatedNeema, M
dash.contributor.affiliatedCavallari, Michele
dash.contributor.affiliatedGlanz, Bonnie
dash.contributor.affiliatedBakshi, Rohit
dash.contributor.affiliatedMoscufo, Nicola
dash.contributor.affiliatedGuttmann, Charles


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