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dc.contributor.authorMatteis, Mariaen_US
dc.contributor.authorPolverino, Francescaen_US
dc.contributor.authorSpaziano, Giuseppeen_US
dc.contributor.authorRoviezzo, Fiorentinaen_US
dc.contributor.authorSantoriello, Carloen_US
dc.contributor.authorSullo, Nikolen_US
dc.contributor.authorBucci, Maria Rosariaen_US
dc.contributor.authorRossi, Francescoen_US
dc.contributor.authorPolverino, Marioen_US
dc.contributor.authorOwen, Caroline Aen_US
dc.contributor.authorD’Agostino, Brunoen_US
dc.date.accessioned2014-08-13T13:59:58Z
dc.date.issued2014en_US
dc.identifier.citationMatteis, M., F. Polverino, G. Spaziano, F. Roviezzo, C. Santoriello, N. Sullo, M. R. Bucci, et al. 2014. “Effects of sex hormones on bronchial reactivity during the menstrual cycle.” BMC Pulmonary Medicine 14 (1): 108. doi:10.1186/1471-2466-14-108. http://dx.doi.org/10.1186/1471-2466-14-108.en
dc.identifier.issn1471-2466en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717548
dc.description.abstractBackground: Many asthmatic women complain of symptom exacerbations in particular periods, i.e. during pregnancy and menstrual cycles (perimenstrual asthma: PMA)". The goal of this study was to study the effect of the luteal and follicular phases of the menstrual cycle on bronchial reactivity (BR) in a group of asthmatic women. Methods: For this purpose, 36 pre-menopausal women were enrolled and underwent testing for resting pulmonary function, measurement of the diffusing capacity of the lung for carbon monoxide (DLCO), and airway responsiveness to methacholine in the follicular and luteal phases of their menstrual cycles. We also measured plasma hormone levels and levels of cyclic adenosine monophosphate (cAMP; a mediator of bronchial smooth muscle contraction) and testosterone in induced sputum samples. Results: Our study showed that about 30% of the asthmatic women had decreased PC20FEV1.0 in the follicular phase of menstrual cycle with a significant correlation between PC20FEV1.0 and serum testosterone levels. Moreover, marked increases in sputum testosterone levels (mean = 2.6-fold increase) together with significant increases in sputum cAMP concentrations (mean = 3.6-fold increases) were observed during the luteal phase of asthmatic patients, suggesting that testosterone contributes to the pathophysiology of PMA. We excluded the possibility that testosterone directly inhibits phosphodiesterase (PDE) activity as incubating PDE with testosterone in vitro did not reduce PDE catalytic activity. Conclusions: In conclusion, our data show that PC20FEV1.0 was decreased in the follicular phase of the menstrual cycle in about 30% of women and was associated with lower cAMP levels in sputum samples, which may contribute to bronchoconstriction. Our results also suggest a link between PMA and testosterone levels. However, whether these findings are of clinical significance in terms of the management of asthma or asthma worsening during the menstrual cycle needs further investigation.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1471-2466-14-108en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106209/pdf/en
dash.licenseLAAen_US
dc.subjectPerimenstrual asthmaen
dc.subjectMenstrual cycleen
dc.subjectTestosteroneen
dc.subjectPhosphodiesterasesen
dc.subjectCyclic AMPen
dc.titleEffects of sex hormones on bronchial reactivity during the menstrual cycleen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Pulmonary Medicineen
dash.depositing.authorPolverino, Francescaen_US
dc.date.available2014-08-13T13:59:58Z
dc.identifier.doi10.1186/1471-2466-14-108*
dash.authorsorderedfalse
dash.contributor.affiliatedOwen, Caroline
dash.contributor.affiliatedPolverino, Francesca
dc.identifier.orcid0000-0001-9686-5698


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