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dc.contributor.authorBhan, Ishiren_US
dc.date.accessioned2014-08-13T14:00:09Z
dc.date.issued2014en_US
dc.identifier.citationBhan, Ishir. 2014. “Vitamin D Binding Protein and Bone Health.” International Journal of Endocrinology 2014 (1): 561214. doi:10.1155/2014/561214. http://dx.doi.org/10.1155/2014/561214.en
dc.identifier.issn1687-8337en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717572
dc.description.abstractVitamin D binding protein (DBP) is the major carrier protein of 25-hydroxyvitamin D (25(OH) D) in the circulation, where it may serve roles in maintaining stable levels during times of decreased 25(OH) availability and in regulating delivery of 25(OH) D to target tissues. Several genetic polymorphisms of DBP have been described that lead to phenotypic changes in the protein that may affect affinity, activity, and concentration. These polymorphisms have been linked with alterations in bone density in several populations. One of the mechanisms by which DBP may alter bone health involves regulating vitamin D bioavailability. DBP-bound vitamin is thought to be relatively unavailable to target tissues, and thus alterations in DBP levels or affinity could lead to changes in vitamin D bioactivity. As a result, functional vitamin D status may differ greatly between individuals with similar total 25(OH) D levels. Additionally, DBP may have independent roles on macrophage and osteoclast activation. This review will summarize recent findings about DBP with respect to measures of bone density and health.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2014/561214en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058579/pdf/en
dash.licenseLAAen_US
dc.titleVitamin D Binding Protein and Bone Healthen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalInternational Journal of Endocrinologyen
dash.depositing.authorBhan, Ishiren_US
dc.date.available2014-08-13T14:00:09Z
dc.identifier.doi10.1155/2014/561214*
dash.contributor.affiliatedBhan, Ishir


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