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dc.contributor.authorLipinski, Boguslawen_US
dc.date.accessioned2014-08-13T14:00:10Z
dc.date.issued2014en_US
dc.identifier.citationLipinski, Boguslaw. 2014. “Iron-induced parafibrin formation in tumors fosters immune evasion.” Oncoimmunology 3 (1): e28539. doi:10.4161/onci.28539. http://dx.doi.org/10.4161/onci.28539.en
dc.identifier.issn2162-4011en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717574
dc.description.abstractAlthough efficacious in vitro, it is well known that adoptive immunotherapeutic modalities lose their potency when applied in vivo. Furthermore, malignant cell exposure to blood platelets attenuates the anticancer activity of natural killer (NK) cells. We argue that upon contact with redox iron, fibrinogen is converted to a hydrophobic fibrin-like polymer that coats tumor cells and provides protection from immune-mediated destruction.en
dc.language.isoen_USen
dc.publisherLandes Bioscienceen
dc.relation.isversionofdoi:10.4161/onci.28539en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063136/pdf/en
dash.licenseLAAen_US
dc.subjectfibrinogenen
dc.subjecthydrophobic bondsen
dc.subjectironen
dc.subjectNK cellsen
dc.subjectparafibrinen
dc.subjectpolyphenolsen
dc.titleIron-induced parafibrin formation in tumors fosters immune evasionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalOncoimmunologyen
dc.date.available2014-08-13T14:00:10Z
dc.identifier.doi10.4161/onci.28539*


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