Discovering cancer immunotherapy targets in vivo
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CitationZhou, Penghui, and Kai W Wucherpfennig. 2014. “Discovering cancer immunotherapy targets in vivo.” Oncoimmunology 3 (1): e28500. doi:10.4161/onci.28500. http://dx.doi.org/10.4161/onci.28500.
AbstractA key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717575
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