Discovering cancer immunotherapy targets in vivo

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Discovering cancer immunotherapy targets in vivo

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Title: Discovering cancer immunotherapy targets in vivo
Author: Zhou, Penghui; Wucherpfennig, Kai W

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Citation: Zhou, Penghui, and Kai W Wucherpfennig. 2014. “Discovering cancer immunotherapy targets in vivo.” Oncoimmunology 3 (1): e28500. doi:10.4161/onci.28500.
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Abstract: A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery of such targets in the tumor microenvironment in vivo utilizing pooled shRNA libraries as a screening tool. Here, we discuss applying this unbiased method to develop innovative cancer therapeutics.
Published Version: doi:10.4161/onci.28500
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