Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells

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Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells

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Title: Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells
Author: Chen, Yihe; Chauhan, Sunil K.; Lee, Hyun Soo; Saban, Daniel R.; Dana, Reza

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Citation: Chen, Yihe, Sunil K. Chauhan, Hyun Soo Lee, Daniel R. Saban, and Reza Dana. 2013. “Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells.” Mucosal immunology 7 (1): 10.1038/mi.2013.20. doi:10.1038/mi.2013.20. http://dx.doi.org/10.1038/mi.2013.20.
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Abstract: Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation remains to be determined. Thus far, only models of acute DED have been used to derive experimental data. This is in contrast to clinical DED which usually presents as a chronic disease. In the present study, using a murine model of chronic DED, it was established that the chronic phase of the disease is accompanied by Th17 responses at the ocular surface, and that a significant memory T cell population can be recovered from chronic DED. This memory response is predominantly mediated by Th17 cells. Moreover, adoptive transfer of this memory T cell population was shown to induce more severe and rapidly progressing DED than did the adoptive transfer of its effector or naïve counterparts. Not only do these results clearly demonstrate that effector memory Th17 cells are primarily responsible for maintaining the chronic and relapsing course of DED, but they also highlight a potentially novel therapeutic strategy for targeting memory immune responses in patients with DED.
Published Version: doi:10.1038/mi.2013.20
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732510/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12717586
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