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dc.contributor.authorBenjamin, Christopher F. A.en_US
dc.contributor.authorSaling, Michael M.en_US
dc.contributor.authorWood, Amanda G.en_US
dc.contributor.authorReutens, David C.en_US
dc.date.accessioned2014-08-13T14:00:23Z
dc.date.issued2014en_US
dc.identifier.citationBenjamin, Christopher F. A., Michael M. Saling, Amanda G. Wood, and David C. Reutens. 2014. “Elemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsy.” PLoS ONE 9 (6): e100891. doi:10.1371/journal.pone.0100891. http://dx.doi.org/10.1371/journal.pone.0100891.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717601
dc.description.abstractThe mesial temporal lobe (MTL) is typically understood as a memory structure in clinical settings, with the sine qua non of MTL damage in epilepsy being memory impairment. Recent models, however, understand memory as one of a number of higher cognitive functions that recruit the MTL through their reliance on more fundamental processes, such as “self-projection” or “association formation”. We examined how damage to the left MTL influences these fundamental processes through the encoding of elemental spatial and temporal associations. We used a novel fMRI task to image the encoding of simple visual stimuli, either rich or impoverished, in spatial or spatial plus temporal information. Participants included 14 typical adults (36.4 years, sd. 10.5 years) and 14 patients with left mesial temporal lobe damage as evidenced by a clinical diagnosis of left temporal lobe epilepsy (TLE) and left MTL impairment on imaging (34.3 years, sd. 6.6 years). In-scanner behavioral performance was equivalent across groups. In the typical group whole-brain analysis revealed highly significant bilateral parahippocampal activation (right > left) during spatial associative processing and left hippocampal/parahippocampal deactivation in joint spatial-temporal associative processing. In the left TLE group identical analyses indicated patients used MTL structures contralateral to the seizure focus differently and relied on extra-MTL regions to a greater extent. These results are consistent with the notion that epileptogenic MTL damage is followed by reorganization of networks underlying elemental associative processes. In addition, they provide further evidence that task-related fMRI deactivation can meaningfully index brain function. The implications of these findings for clinical and cognitive neuropsychological models of MTL function in TLE are discussed.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0100891en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076213/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectNeuroscienceen
dc.subjectCognitive Scienceen
dc.subjectCognitionen
dc.subjectMemoryen
dc.subjectCognitive Psychologyen
dc.subjectNeuropsychologyen
dc.subjectPsychologyen
dc.subjectMedicine and Health Sciencesen
dc.subjectDiagnostic Medicineen
dc.subjectDiagnostic Radiologyen
dc.subjectMagnetic Resonance Imagingen
dc.subjectMental Health and Psychiatryen
dc.subjectNeurologyen
dc.subjectEpilepsyen
dc.subjectTemporal Lobe Epilepsyen
dc.subjectRadiology and Imagingen
dc.subjectSocial Sciencesen
dc.titleElemental Spatial and Temporal Association Formation in Left Temporal Lobe Epilepsyen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorBenjamin, Christopher F. A.en_US
dc.date.available2014-08-13T14:00:23Z
dc.identifier.doi10.1371/journal.pone.0100891*
dash.contributor.affiliatedBenjamin, Christopher


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