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dc.contributor.authorKanaoka, Yoshihideen_US
dc.contributor.authorBoyce, Joshua A.en_US
dc.date.accessioned2014-08-13T14:00:28Z
dc.date.issued2014en_US
dc.identifier.citationKanaoka, Yoshihide, and Joshua A. Boyce. 2014. “Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts.” Allergy, Asthma & Immunology Research 6 (4): 288-295. doi:10.4168/aair.2014.6.4.288. http://dx.doi.org/10.4168/aair.2014.6.4.288.en
dc.identifier.issn2092-7355en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12717613
dc.description.abstractCysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulation of cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptor for the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.en
dc.language.isoen_USen
dc.publisherThe Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Diseaseen
dc.relation.isversionofdoi:10.4168/aair.2014.6.4.288en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077954/pdf/en
dash.licenseLAAen_US
dc.subjectLeukotrienesen
dc.subject5-lipoxygenaseen
dc.subjectasthmaen
dc.subjectAERDen
dc.titleCysteinyl Leukotrienes and Their Receptors; Emerging Conceptsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalAllergy, Asthma & Immunology Researchen
dash.depositing.authorKanaoka, Yoshihideen_US
dc.date.available2014-08-13T14:00:28Z
dc.identifier.doi10.4168/aair.2014.6.4.288*
dash.contributor.affiliatedKanaoka, Yoshihide
dash.contributor.affiliatedBoyce, Joshua


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