Detection and characterization of translational research in cancer and cardiovascular medicine

DSpace/Manakin Repository

Detection and characterization of translational research in cancer and cardiovascular medicine

Citable link to this page

 

 
Title: Detection and characterization of translational research in cancer and cardiovascular medicine
Author: Jones, David Shumway; Cambrosio, Alberto; Mogoutov, Andrei

Note: Order does not necessarily reflect citation order of authors.

Citation: Jones, David S., Alberto Cambrosio, and Andrei Mogoutov. 2011. Detection and Characterization of Translational Research in Cancer and Cardiovascular Medicine. Journal of Translational Medicine 9(1): 57.
Full Text & Related Files:
Abstract: Background
Scientists and experts in science policy have become increasingly interested in strengthening translational research. Efforts to understand the nature of translational research and monitor policy interventions face an obstacle: how can translational research be defined in order to facilitate analysis of it? We describe methods of scientometric analysis that can do this.

Methods
We downloaded bibliographic and citation data from all articles published in 2009 in the 75 leading journals in cancer and in cardiovascular medicine (roughly 15,000 articles for each field). We calculated citation relationships between journals and between articles and we extracted the most prevalent natural language concepts.

Results
Network analysis and mapping revealed polarization between basic and clinical research, but with translational links between these poles. The structure of the translational research in cancer and cardiac medicine is, however, quite different. In the cancer literature the translational interface is composed of different techniques (e.g., gene expression analysis) that are used across the various subspecialties (e.g., specific tumor types) within cancer research and medicine. In the cardiac literature, the clinical problems are more disparate (i.e., from congenital anomalies to coronary artery disease); although no distinctive translational interface links these fields, translational research does occur in certain subdomains, especially in research on atherosclerosis and hypertension.

Conclusions
These techniques can be used to monitor the continuing evolution of translational research in medicine and the impact of interventions designed to enhance it.
Published Version: doi:10.1186/1479-5876-9-57
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12724018
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters