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dc.contributor.authorKnowles, Robert R.
dc.contributor.authorJacobsen, Eric N.
dc.date.accessioned2014-08-19T20:30:33Z
dc.date.issued2010
dc.identifier.citationKnowles, Robert R., and Eric N. Jacobsen. 2010. Attractive Noncovalent Interactions in Asymmetric Catalysis: Links Between Enzymes and Small Molecule Catalysts. Proceedings of the National Academy of Sciences 107, no. 48: 20678–20685.en_US
dc.identifier.issn0027-8424en_US
dc.identifier.issn1091-6490en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12724033
dc.description.abstractCatalysis by neutral, organic, small molecules capable of binding and activating substrates solely via noncovalent interactions—particularly H-bonding—has emerged as an important approach in organocatalysis. The mechanisms by which such small molecule catalysts induce high enantioselectivity may be quite different from those used by catalysts that rely on covalent interactions with substrates. Attractive noncovalent interactions are weaker, less distance dependent, less directional, and more affected by entropy than covalent interactions. However, the conformational constraint required for high stereoinduction may be achieved, in principle, if multiple noncovalent attractive interactions are operating in concert. This perspective will outline some recent efforts to elucidate the cooperative mechanisms responsible for stereoinduction in highly enantioselective reactions promoted by noncovalent catalysts.en_US
dc.description.sponsorshipChemistry and Chemical Biologyen_US
dc.language.isoen_USen_US
dc.publisherProceedings of the National Academy of Sciencesen_US
dc.relation.isversionofdoi:10.1073/pnas.1006402107en_US
dash.licenseLAA
dc.subjectenantioselectivityen_US
dc.subjectH bondingen_US
dc.subjectorganocatalysisen_US
dc.subjecttransition state stabilizationen_US
dc.titleAttractive Noncovalent Interactions in Asymmetric Catalysis: Links Between Enzymes and Small Molecule Catalystsen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalProceedings of the National Academy of Sciencesen_US
dash.depositing.authorJacobsen, Eric N.
dash.waiver2010-09-22
dc.date.available2014-08-19T20:30:33Z
dc.identifier.doi10.1073/pnas.1006402107*
workflow.legacycommentsFrom Waiver Tableen_US
dash.contributor.affiliatedJacobsen, Eric


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