Nanoscale Label-free Bioprobes to Detect Intracellular Proteins in Single Living Cells
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CitationHong, Wooyoung, Feng Liang, Diane Schaak, Marko Loncar, and Qimin Quan. 2014. “Nanoscale Label-free Bioprobes to Detect Intracellular Proteins in Single Living Cells.” Scientific Reports 4 (1): 6179. doi:10.1038/srep06179. http://dx.doi.org/10.1038/srep06179.
AbstractFluorescent labeling techniques have been widely used in live cell studies; however, the labeling processes can be laborious and challenging for use in non-transfectable cells, and labels can interfere with protein functions. While label-free biosensors have been realized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and in living cells has not been found. Here we present the first demonstration of label-free detection of intracellular p53 protein dynamics through a nanoscale surface plasmon-polariton fiber-tip-probe (FTP).
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785852
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