Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

DSpace/Manakin Repository

Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

Citable link to this page

 

 
Title: Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?
Author: Rahman, Samir; Gadjeva, Mihaela

Note: Order does not necessarily reflect citation order of authors.

Citation: Rahman, Samir, and Mihaela Gadjeva. 2014. “Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?” Frontiers in Immunology 5 (1): 378. doi:10.3389/fimmu.2014.00378. http://dx.doi.org/10.3389/fimmu.2014.00378.
Full Text & Related Files:
Abstract: Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biological significance of NETosis in acute and chronic pathologic conditions. This review highlights the latest knowledge regarding NET structures, deployment, and function, with an emphasis on current understanding of NET proteomes, their conservation, and significance in the context of cystic fibrosis (CF), a condition characterized by excessive extracellular DNA/NET presence. We also discuss how our understanding of NETosis yields novel therapeutic approaches and their applicability to CF.
Published Version: doi:10.3389/fimmu.2014.00378
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127480/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785872
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters