Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

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Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?

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dc.contributor.author Rahman, Samir en_US
dc.contributor.author Gadjeva, Mihaela en_US
dc.date.accessioned 2014-09-08T15:36:51Z
dc.date.issued 2014 en_US
dc.identifier.citation Rahman, Samir, and Mihaela Gadjeva. 2014. “Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis?” Frontiers in Immunology 5 (1): 378. doi:10.3389/fimmu.2014.00378. http://dx.doi.org/10.3389/fimmu.2014.00378. en
dc.identifier.issn 1664-3224 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785872
dc.description.abstract Significant advances in our understanding of neutrophil biology were made in the past several years. The exciting discovery that neutrophils deploy neutrophil extracellular traps (NETs) to catch pathogens paved the way for a series of additional studies to define the molecular mechanisms of NET generation and the biological significance of NETosis in acute and chronic pathologic conditions. This review highlights the latest knowledge regarding NET structures, deployment, and function, with an emphasis on current understanding of NET proteomes, their conservation, and significance in the context of cystic fibrosis (CF), a condition characterized by excessive extracellular DNA/NET presence. We also discuss how our understanding of NETosis yields novel therapeutic approaches and their applicability to CF. en
dc.language.iso en_US en
dc.publisher Frontiers Media S.A. en
dc.relation.isversionof doi:10.3389/fimmu.2014.00378 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127480/pdf/ en
dash.license LAA en_US
dc.subject Perspective Article en
dc.subject neutrophils en
dc.subject NETs en
dc.subject histones en
dc.subject neutrophil elastase en
dc.subject chromatin en
dc.subject cystic fibrosis en
dc.subject en
dc.title Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis? en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal Frontiers in Immunology en
dash.depositing.author Gadjeva, Mihaela en_US
dc.date.available 2014-09-08T15:36:51Z

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