MYC is essential for the formation and maintenance of germinal centers
Calado, Dinis Pedro
Godinho, Susana A.
Sleckman, Barry P.
de Alborán, Ignacio Moreno
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CitationCalado, Dinis Pedro, Yoshiteru Sasaki, Susana A. Godinho, Alex Pellerin, Karl Köchert, Barry P. Sleckman, Ignacio Moreno de Alborán, Martin Janz, Scott Rodig, and Klaus Rajewsky. 2013. “MYC is essential for the formation and maintenance of germinal centers.” Nature immunology 13 (11): 1092-1100. doi:10.1038/ni.2418. http://dx.doi.org/10.1038/ni.2418.
AbstractGerminal centers (GC) are sites of intense B cell proliferation, central for T cell dependent antibody responses. However, the role of MYC, a key cell cycle regulator, in this process has been questioned. Here, we identified MYC positive B cell subpopulations in immature and mature GCs, and show through genetic ablation of Myc that they play indispensable roles in GC formation and maintenance. The identification of these functionally critical cellular subsets has important implications for human B cell lymphomagenesis, which mostly originates from GC B cells and frequently involves MYC chromosomal translocations. As these translocations are generally dependent on transcription of the recombining partner loci, the MYC positive GC subpopulations may be at a particularly high risk for malignant transformation.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785890
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