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dc.contributor.authorCalado, Dinis Pedroen_US
dc.contributor.authorSasaki, Yoshiteruen_US
dc.contributor.authorGodinho, Susana A.en_US
dc.contributor.authorPellerin, Alexen_US
dc.contributor.authorKöchert, Karlen_US
dc.contributor.authorSleckman, Barry P.en_US
dc.contributor.authorde Alborán, Ignacio Morenoen_US
dc.contributor.authorJanz, Martinen_US
dc.contributor.authorRodig, Scotten_US
dc.contributor.authorRajewsky, Klausen_US
dc.date.accessioned2014-09-08T15:37:01Z
dc.date.issued2013en_US
dc.identifier.citationCalado, Dinis Pedro, Yoshiteru Sasaki, Susana A. Godinho, Alex Pellerin, Karl Köchert, Barry P. Sleckman, Ignacio Moreno de Alborán, Martin Janz, Scott Rodig, and Klaus Rajewsky. 2013. “MYC is essential for the formation and maintenance of germinal centers.” Nature immunology 13 (11): 1092-1100. doi:10.1038/ni.2418. http://dx.doi.org/10.1038/ni.2418.en
dc.identifier.issn1529-2908en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785890
dc.description.abstractGerminal centers (GC) are sites of intense B cell proliferation, central for T cell dependent antibody responses. However, the role of MYC, a key cell cycle regulator, in this process has been questioned. Here, we identified MYC positive B cell subpopulations in immature and mature GCs, and show through genetic ablation of Myc that they play indispensable roles in GC formation and maintenance. The identification of these functionally critical cellular subsets has important implications for human B cell lymphomagenesis, which mostly originates from GC B cells and frequently involves MYC chromosomal translocations. As these translocations are generally dependent on transcription of the recombining partner loci, the MYC positive GC subpopulations may be at a particularly high risk for malignant transformation.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/ni.2418en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132664/pdf/en
dash.licenseLAAen_US
dc.titleMYC is essential for the formation and maintenance of germinal centersen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature immunologyen
dc.date.available2014-09-08T15:37:01Z
dc.identifier.doi10.1038/ni.2418*


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