A Direct Projection from Mouse Primary Visual Cortex to Dorsomedial Striatum
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CitationKhibnik, Lena A., Nicolas X. Tritsch, and Bernardo L. Sabatini. 2014. “A Direct Projection from Mouse Primary Visual Cortex to Dorsomedial Striatum.” PLoS ONE 9 (8): e104501. doi:10.1371/journal.pone.0104501. http://dx.doi.org/10.1371/journal.pone.0104501.
AbstractThe mammalian striatum receives inputs from many cortical areas, but the existence of a direct axonal projection from the primary visual cortex (V1) is controversial. In this study we use anterograde and retrograde tracing techniques to demonstrate that V1 directly innervates a topographically defined longitudinal strip of dorsomedial striatum in mice. We find that this projection forms functional excitatory synapses with direct and indirect pathway striatal projection neurons (SPNs) and engages feed-forward inhibition onto these cells. Importantly, stimulation of V1 afferents is sufficient to evoke phasic firing in SPNs. These findings therefore identify a striatal region that is functionally innervated by V1 and suggest that early visual processing may play an important role in striatal-based behaviors.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785903
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