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dc.contributor.authorLiang, Jianfengen_US
dc.contributor.authorTong, Panen_US
dc.contributor.authorZhao, Wannien_US
dc.contributor.authorLi, Yaqiaoen_US
dc.contributor.authorZhang, Lien_US
dc.contributor.authorXia, Yingen_US
dc.contributor.authorYu, Yanbingen_US
dc.date.accessioned2014-09-08T15:37:09Z
dc.date.issued2014en_US
dc.identifier.citationLiang, Jianfeng, Pan Tong, Wanni Zhao, Yaqiao Li, Li Zhang, Ying Xia, and Yanbing Yu. 2014. “The REST Gene Signature Predicts Drug Sensitivity in Neuroblastoma Cell Lines and Is Significantly Associated with Neuroblastoma Tumor Stage.” International Journal of Molecular Sciences 15 (7): 11220-11233. doi:10.3390/ijms150711220. http://dx.doi.org/10.3390/ijms150711220.en
dc.identifier.issn1422-0067en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12785905
dc.description.abstractNeuroblastoma is the most common and deadly solid tumor in children, and there is currently no effective treatment available for neuroblastoma patients. The repressor element-1 silencing transcription (REST) factor has been found to play important roles in the regulation of neural differentiation and tumorigenesis. Recently, a REST signature consisting of downstream targets of REST has been reported to have clinical relevance in both breast cancer and glioblastoma. However it remains unclear how the REST signature works in neuroblastoma. Publicly available datasets were mined and bioinformatic approaches were used to investigate the utility of the REST signature in neuroblastoma with both preclinical and real patient data. The REST signature was found to be associated with drug sensitivity in neuroblastoma cell lines. Further, neuroblastoma patients with enhanced REST activity are significantly associated with higher clinical stages. Loss of heterozygosity on chromosome 11q23, which occurs in a large subset of high-risk neuroblastomas, tends to be correlated with high REST activity, with marginal significance. In conclusion, the REST signature has important implications for targeted therapy, and it is a prognostic factor in neuroblastoma patients.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/ijms150711220en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139778/pdf/en
dash.licenseLAAen_US
dc.subjectRESTen
dc.subjectneuron-restrictive silencer factoren
dc.subjectneuroblastomaen
dc.subjecttumor stageen
dc.subjectdrug sensitivityen
dc.subjectchemotherapeutic targeten
dc.titleThe REST Gene Signature Predicts Drug Sensitivity in Neuroblastoma Cell Lines and Is Significantly Associated with Neuroblastoma Tumor Stageen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalInternational Journal of Molecular Sciencesen
dash.depositing.authorLi, Yaqiaoen_US
dc.date.available2014-09-08T15:37:09Z
dc.identifier.doi10.3390/ijms150711220*
dash.contributor.affiliatedLi, Yaqiao


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