Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design

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Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design

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Title: Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design
Author: Rucevic, Marijana; Boucau, Julie; Dinter, Jens; Kourjian, Georgio; Le Gall, Sylvie

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Citation: Rucevic, Marijana, Julie Boucau, Jens Dinter, Georgio Kourjian, and Sylvie Le Gall. 2014. “Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design.” Viruses 6 (8): 3271-3292. doi:10.3390/v6083271. http://dx.doi.org/10.3390/v6083271.
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Abstract: The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells. Despite a wealth of information about peptidases involved in protein degradation, our knowledge of epitope presentation during HIV infection remains limited. Here we review current data on HIV protein degradation linking epitope production and immunodominance, viral evolution and impaired epitope presentation. We propose that an in-depth understanding of HIV antigen processing and presentation in relevant primary cells could be exploited to identify signatures leading to efficient or inefficient epitope presentation in HIV proteomes, and to improve the design of immunogens eliciting immune responses efficiently recognizing all infected cells.
Published Version: doi:10.3390/v6083271
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147695/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:12785932
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